• Announcements

    • Joelf

      Upgraded Sclero Forums!   05/18/2017

      Welcome to the Upgraded and Redesigned Sclero Forums!!   Our Forums are even better and more up to date than before.   Happy Posting to all our Members!!
Sign in to follow this  
Followers 0

Question About SCL70 Test

4 posts in this topic

Hi Everyone,


I tested positive for scleroderma in 12/08 (SCL70 test) and now it comes up negative. Could it be Lupus attributing to the initial positive test? I just read that Lupus can cause a false positive on that test - is there data to back that up? I am being treated as if I have MCTD until we cannot rule out scleroderma. I have had numerous tests and the PFT came up slightly abnormal re: diffuse capacity. I am scheduled for a high resolution chest cat scan and cardio testing. Any help would be greatly appreciated - thanks :) Lori

Share this post

Link to post
Share on other sites

Hi Lori,


I've found a couple of links to Antibodies in SLE and Anti-SCL70 antibodies in SLE which I hope you'll find interesting.


Bear in mind though that people can have Scleroderma and other autoimmune problems and yet the blood tests can be negative and vice versa so blood tests are by no means conclusive. Your rheumatologist will probably have a clearer picture once you've had the CT scan and the cardio testing, together with the results of the PFT. I know when I first went to the lung hospital they did all manner of lung and blood tests imaginable and to start with they weren't totally sure that I had Scleroderma. It was only really when they correlated all the information together, plus they could tell the nature of the interstitial lung disease I had by the pattern of ground glass on my lungs, which led them to the diagnosis of Scleroderma.


Do let us know the results of your CT scan and cardio testing.

Jo Frowde

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

ISN Chat Host

International Scleroderma Network (ISN)

Share this post

Link to post
Share on other sites

Hello Lori


Well I have and have always had a negative SCL-70 but have diffuse scleroderma with internal organ involvement. Jo's right in that test results are going to be more telling for you than blood work alone.


Whatever your final diagnosis may be at least your treatment is in good hands.


Take care.

Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

ISN Video Presentations Manager

ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist

International Scleroderma Network (ISN)

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  
Followers 0