Tbhof

Low positive ANA

8 posts in this topic

Hi everyone. I went back to my doctor to redo the ANA as I wasn't sure what method was used. It came back 1:80 speckled. ENA was also run. In that, Scl-70 and Ribonucleoprotein (RNP) came back negative as well as for Sjogrens.
Can anyone tell me what speckled means? What a low reading may mean? Thank you!

Share this post


Link to post
Share on other sites

Hi,

 

When I was diagnosed my ANA result was Centromere Pattern 1:1280.

 

As far as I know, not having worked in a lab. since 1966!!, these patterns are created when the sample is treated and then looked at under a microscope.

Speckled and Centromere are patterns which indicate Scleroderma (and other things too) and the numbers expressed in a ratio indicate the 'strength' of the reaction.

So the way I understand it 1:80 is low and 1:1280 is stronger.   I don't know how high they go, could be astronomical or not!!!   It would be interesting to hear what ratio others on here have got.

 

This is a very simplistic description because I haven't even got a current first aid certificate, and my memories are from a VERY long time ago.

 

Best wishes

Judyt

Share this post


Link to post
Share on other sites

Hi....Gareth's ANA was positive, speckled pattern, diffuse cytoplasm, 1:80, per Dr Metzer's lab.  Scl-70 and ACA were negative.  Anti-RNA 1/111 has been positive 3 times.  With those results and esophageal dismotility + internal involvement, he does not have the *scleroderma* dx, but UCTD. 

 

Hi Jo and Amanda....we got home last week. Loved England and Ireland!!!

 

Take care, Everyone.

Margaret

Mom to Gareth, 27 years old, DS/ASD

Share this post


Link to post
Share on other sites

Hi Tbhof,

 

As with a lot of the antibody tests, they really do need to be taken in conjunction with all the clinical symptoms as well.

 

I've found a useful link for you about the Antinuclear Antibody test which explains about the speckled antibodies in more detail. It does sound as though your results are good as the readings do seem to be quite low (I think 1:40 is considered within the normal range, so 1:80 does seem quite acceptable.)

 

Kind regards,

 

 
 


Jo Frowde

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

International Scleroderma Network (ISN)

Share this post


Link to post
Share on other sites

Hi Margaret,

 

I'm so pleased you had a lovely holiday and arrived back home safely.

 

How lucky you were with the weather; it's pouring with rain today, as per usual!! :wink:

 

Here's a special "hello" for Gareth and I'm really hoping his operation goes well.

:hug-bear: :hug-bear:


Jo Frowde

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

International Scleroderma Network (ISN)

Share this post


Link to post
Share on other sites

Hi 

 

My bloods came back exactly the same as yours Judy! I was told this was the Limited Cutaneous Systemic Sclerosis. Mine was also diagnosed along with the medical notes taken and a physical examination.

 

Buttons

Share this post


Link to post
Share on other sites

Some labs say 1:80 is a negative result. My primary doctor says its insignificant. I'm just not sure what to think!!

Share this post


Link to post
Share on other sites

Hi Tbhof,

 

Systemic scleroderma is a clinical diagnosis, meaning that it is based upon symptoms and not upon bloodwork.  A person could have off-the-charts positive antibodies but without any telling symptoms, would not carry a diagnosis of scleroderma -- a suspicion of it possibly occurring at some point, of course, but that is very different than actual diagnosis.

 

As well, a person can have entirely negative antibodies but still be diagnosed with scleroderma, based upon symptoms alone.

 

Since your antibodies are "insignificant", or possibly even "negative", then the question reverts back to your present symptoms.

 

Autoimmunity can come and go; it is not always a continually persistent thing. It's better to think of antibodies as a clue, one that sometimes (but not always) solves the mystery, but for some of us the clue that solves it, especially in the beginning, isn't the lab work, but rather other things, like unmistakable tight skin or lung fibrosis, combined with other symptoms.  See Difficult Diagnosis.


Warm Hugs,

 

Shelley Ensz

Founder and President

International Scleroderma Network (ISN)

Hotline and Donations: 1-800-564-7099

 

The most important thing in the world to know about scleroderma is sclero.org.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now