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Very High ANA and Centromere Titer

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Hi! I am a 30 year old female with 1 child. I had an ANA test because a doctor wanted to make sure my silicone implants were not affecting me. My ANA came back very high which started this journey!


I went to a hematologist and tested positive for MTHFR and Antiphospholipid syndrome


I went to a rheumatologist who said I seem healthy and have no symptoms.

My bloodwork just came back that I still have high ANA 1:2800 and Positive centromere Titer. My rheumatoid factor is 17.


What can be causing all of this with no symptoms at all? Should I be worried. This is a lot of information to understand.


Thanks so much

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Hi EML422,


Welcome to Sclero Forums.


I'm sorry you have antibodies, but just in general, antibodies are typically only worrisome if/when they are accompanied by certain symptoms.


We have many threads on this general topic of antibodies without symptoms, so while you are waiting for other responses, I'd suggest searching through our forums on this general topic.



Warm Hugs,


Shelley Ensz

Founder and President

International Scleroderma Network (ISN)

Hotline and Donations: 1-800-564-7099


The most important thing in the world to know about scleroderma is sclero.org.

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Hi EML422,


Welcome to these forums!


I'm sorry to hear that you have worries regarding a positive blood test for antibodies. However, blood tests are only a very small part of the diagnostic tools used to determine whether full blown scleroderma will develop, as the clinical symptoms should always be taken into account as well.


As Shelley has advised, we have numerous threads on this very subject and if you use the search facility at the top right hand corner of the forums and type in "positive antibodies", you can bring up lots more information about this, which I hope you'll find helpful and informative.


Kind regards,

Jo Frowde

ISN Board Member

ISN Secretary of the Board

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

International Scleroderma Network (ISN)

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