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Hi everyone,

I am currently in the process of trying to figure out what is going on with me!

I have Raynaud’s, GERD, puffy fingers (especially in the am) joint pain, muscle pain, extreme fatigue....

My primary care physician ran lab tests and the results were a positive ANA, positive Anti Centromere B, and a positive RNA Polymerase III. 

I’ve read that people usually have 1 of the main 3 tests come back positive, but not 2 of them. 

Anybody have any thoughts on this?

Thank you!


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Hi Tracy,


As we said before in your other thread, the blood tests are only a part of the diagnostic process, and positive antibodies do not always mean that you will develop full blown scleroderma.


Have you had your referral and an appointment with the University of California, San Francisco (UCSF) yet? They are really the best people to advise you about the results of your blood tests and any future treatment you might need.


Kind regards,

Jo Frowde

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International Scleroderma Network (ISN)

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Hi Tracy, Gareth had a + ANA (speckled pattern) and   + anti-RNA Polymerase 1/111.  His initial diagnosis of sine scleroderma was changed to UCTD (Undifferentiated connective tissue disease) by the scleroderma specialist.  It's still autoimmune issues - just a different name.  :dont-know:



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