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Crabbycat

Positive SCL70 but also DFS70?

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Hi there.

 

I searched for DFS70 but got zero results so please excuse me of this has been discussed earlier. I'm very confused about these antibodies. I have been diagnosed with Systemic Sclerosis. My ANA was 1:320 with the "dense fine speckled pattern". I also then tested positive for SCL-70 which was 1.8 .  The note from the lab said that the "dense fine speckled pattern indicates the presence of the DFS70 antibody which has a low prevalence in systemic autoimmune rheumatic diseases".

 

So do I really have Systemic Sclerosis? I sure don't want to be taking all this medicine if I don't have to be! 

 

Thank you!

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Hi Crabbycat,

 

Welcome to these forums!

 

The subject of antibodies is very popular on these forums and we have numerous threads about them; although they do have a place in the scleroderma diagnosis, they are only a very small part of the whole picture. We have members with full blown scleroderma, who have negative blood tests and vice versa. The clinical signs and symptoms of the disease is much more important and it is more helpful to you to try not to think of the antibodies as meaning very much other than a possible indicator.

 

I've found an interesting article about the DFS70 antibody, which may be of interest to you, Measurement of anti-DFS70 antibodies in patients with ANA-associated autoimmune rheumatic diseases suspicion is cost-effective, which I hope you find useful. However, the best person to explain the results of your blood tests is your doctor, or preferably a listed scleroderma expert, whom we do recommend that our members consult, as they are the best person to deal with such a complex disease as scleroderma. Certainly they can advise you on the correct diagnosis and medication to take.

 

Kind regards,


Jo Frowde

ISN Board Member

ISN Secretary of the Board

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

International Scleroderma Network (ISN)

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I tried to read the article but couldn't really understand it. It appeared to say that none of the patients that had positive DFS70 ever developed a SARD? So does that mean even though my two tests (scleroderma diagnostic profile) said positive for SCL-70, I don't really have Systemic Sclerosis because I also have DFS70?

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Hi Crabbycat,

 

I can understand your confusion, but as said previously, the best person to explain the results of your blood tests is your scleroderma expert/rheumatologist.

 

Kind regards,


Jo Frowde

ISN Board Member

ISN Secretary of the Board

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

International Scleroderma Network (ISN)

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