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Changes in Blood Tests

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Hi Everyone,


I am 24 years old. In May I starting getting frequent UTI's, having low grade fever, Raynaud's, mouth ulcers, fatigue, joint paint, muscle weakness etc. I came up ana positive (1:640) titler with homogenous pattern, Scl-70 positive and RNP ab positive. The doctor diagnosed me overlap of scleroderma and UCTD.


Now in December I went to a new doctor because I moved and my blood tests came back differently. I am still ana positive (1:640) but with a speckled pattern. I am no longer Sc-70 positive or RNP ab. Is that normal to have an ana pattern change AND to go from positive antibody results to negative in 6 months. 

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Hi Gradstudent24,


Welcome to these forums!


I'm sorry to hear that you've been diagnosed with overlap scleroderma and Undifferentiated Connective Tissue Disease (UCTD). The problem with diagnosing such a complex disease as scleroderma, is that it can mimic other connective issue diseases and when a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called UCTD.


It's quite possible for blood test results to vary from test to test (it can even depend on the different labs where the blood is sent.) Yet again, I would reiterate that blood tests are only a guide and should not be taken as the be all and end all. Please refer to our sticky thread regarding the importance of blood test results.


Kind regards,

Jo Frowde

ISN Board Member

ISN Secretary of the Board

ISN Assistant Webmaster

SD World Webmaster

ISN Sclero Forums Manager

ISN News Manager

ISN Hotline Support Specialist

International Scleroderma Network (ISN)

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