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Equivocal ANA but positive anti RNP

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Hi. I’m very new to this forum & need some advice/support.


I have been very sick for around 20 plus years with an illness that any Dr can't seem to diagnose. I have these horrible flares or exacerbations of the same symptoms over and over. Always exactly the same an now has affected my adrenal glands causing deadly low cortisol levels. I finally found an endocrinologist who is trying to help and is the first Dr that has listened.


I accidentally came across some blood work from a Dr from 2012 where I had an equivocal Ana ( range 5-9) mine was 9 and then a positive anti RNP. I don’t know what, if anything, this could mean, plus I want to be knowledgeable when I see my endocrinologist on Monday and ask for the labs to be repeated. Also do I need to be in a flare when I do the labs if he wants them repeated? Should I ask for a biopsy? Thank you.


This is all new to me as I was just diagnosed with the low cortisol in June of this year. I’m now on 50 mg total of hydrocortisone per day & still have these exacerbations when I get really stressed or sick. My symptoms are crippling muscle and joint pain and am now in a wheelchair,  mouth ulcers & pain, nausea, heart issues like chest pain and atrial fibrillation, severe memory loss and sometimes turns into psychosis but only during exacerbations, passing out, nerve pain, swelling of face & neck, sometimes fever, shortness of breath, severely dry mouth and eyes. I also now have high pressures in my eyes & damage to my right optic nerve. My face also turns a very dark deep red!


Any help on this would be greatly appreciated. I read where a positive anti RNP & Ana usually meant Mixed Connective Tissue Disorder. Thank you. 

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Hi Lisa,


Welcome to these forums.


I'm sorry to hear that you've been suffering for so long with such a plethora of different symptoms. Please note that I have no medical training and the symptoms you describe could relate to any number of health issues and not necessarily scleroderma or any connective tissue disease.


The best person to advise you is your doctor/ endocrinologist when you have your next appointment and judging by the number of different symptoms you describe, it may be necessary for you to have further referrals to other specialists.


Kind regards,


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