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Hormone Replacement Therapy

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My doctor says that most likely the progression of my limited scleroderma is linked to changes in my hormones (most recently the onset of pre-menopause).


Has anyone heard of this before?


If so, does it then follow that hormone replacement therapy could affect the pace of progression?




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First of all, I'd like to welcome you to the ISN forums! I'm so glad you've joined, but sorry it's due to your having had developed scleroderma. I also developed scleroderma while I was peri-menopausal so I do believe that some of the onset was due to hormones. I've also noticed that some of our members developed systems during or after pregnancy.
Hormones are a possible cause of scleroderma. The link will take you to a couple of studies that show the relationship. I've talked to both my primary care physician and rheumatologist about hormone replacement and neither one of them recommend them. I really don't want to take them anyway. I'm on enough meds. I think whether or not to go on HRT is dependent on the individual and the doctors.

I hope you find something interesting in the link.

Big Hugs,

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi Satya,


I sent you a PM as well, but this topic caught my attention. I tried HRT, and quite frankly saw no difference in symptoms or progression, although that was one of the reasons for starting it. My hormones tend to be out of whack most of the time due to my weight (it's hard to stay above 102 lbs. and I'm 5' 5"), and in 2005 went into a wonderful "temporary menopause" for several months. Ok, they call it dysmenorrhea, but I actually felt far better without Aunt Flo coming to visit, and on HRT she moved in permanently. The biggest problem that can occur with HRT is that you tend to end up with mainly estrogen replacement while other hormones are pretty much ignored. Do a lot of reading on the subject and get several medical opinions before starting!


Peace to you too,



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Welcome to the ISN Sclero Forums, Satya. My symptoms didn't show up until well past the onset of menopause. I did not take HRT because my mother had breast cancer. I held a personal opinion that the body stops producing those hormones when it was time to do so. I intend to have a closer look at Janey's link later. Elehos is right about the effect of weight on hormones, both ways. My doctors wanted to blame my uterine cancer on hormones that are produced in fat cells.


I am glad you found us and hope you will agree that this is a great place to come to share information and support. Please feel free to add a post to our Getting to Know You thread when you get a chance.

Warm wishes,



Carrie Maddoux

(Retired)ISN Sclero Forums Support Specialist

(Retired)ISN Sclero Forums UK Chat Host

International Scleroderma Network (ISN)

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