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Sine Scleroderma

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Hi, I just saw another post about Sine Scleroderma, could someone please tell me what type of antibodies you need to have to be diagnosed with this.


I was diagnosed this year as many of you know with Limited/crest scleroderma, but have no skin involvement as yet, everything is internal.


I have a high ANA - 1600, and have also tested positive for anti-centromere antibodies.


Many thanks

Celia :)

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Hi Celia ,


Gareth has no skin invovlment, either. He has a high sed rate (anywhere from 40-98) ANA is positive (speckled pattern, cytoplasm diffuse), negative ACA, positive AntiRNA-Polymerase 1/111, negative Scl-70, and negative Anti-Th/To.


Since he's only 19, I think they are having a hard time pinpointing the definitive diagnosis.....it's UCTD vs sine Scleroderma. Like you, his is all internal.....lungs, vocal cords, esophagus, and renal.


Take care, Everyone.


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One of the articles upder are sine scleroderma section is


Sclerosis Sine Scleroderma May Not Be All That Rare


It states


All the trial participants had progressive interstitial lung disease, severe GERD, and telangiectasias, and all were positive for nucleolar antinuclear antibodies. All six were negative for anticentromere antibodies.


There were 555 partiicipants. It's an interesting article.


Big Hugs,

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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