elizabethmarie

Scl-70 Test

18 posts in this topic

Several times I have tested positive for the scl-70 test. Could raynauds cause this?

I also have a positive ANA.

 

Newbie here,

elizabethmarie

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elizabethmarie,
Welcome to the forums! Based on your question, it appears that you are in the testing or diagnostic phase. Have you been diagnosed with anything?

I couldn't find any relationship between scl-70 and raynaud's. In most of the literature and in some of the articles on the ISN antibodies page, scl-70 is said to be scleroderma specific; however, not everyone with scleroderma has a postive scl-70. A positive ANA (auto-nuclear antibodies) indicates that an autoimmune disease may be present. However, there are members of this forum that have a negative ANA and scleroderma. I have a positive ANA and a negative scl-70. I have systemic scleroderma (SSc).

Again, welcome! So glad that you have joined us. Please tell us more about yourself.

Big Hugs,


Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi, elizabethmarie, and welcome to the ISN Sclero Forums. As Janey says, the ANA is not always definitive one way or the other, but the ANA panels help to get the diagnosis pointed in the right direction. I am also interested in learning more about where the investigation has taken you so far. You will find this a very informative place with a huge amount of support from the great group of members and moderators. Again, welcome.


Warm wishes,

Jefa

 

Carrie Maddoux

(Retired)ISN Sclero Forums Support Specialist

(Retired)ISN Sclero Forums UK Chat Host

International Scleroderma Network (ISN)

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Hi elizabethmarie,

 

Welcome to the Sclero Forums! Really really glad to have you with us. You will find so much information here, support and people who truly understand what you are going through.

 

Again welcome!


Warm and gentle hugs,

 

Pamela

ISN Support Specialist

International Scleroderma Network (ISN)

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Hi and welcome!!

 

I have a positive scl-70 and do not have raynauds. My test was 42. I also have a positive ANA at 1:640. Hope this helps.


Hugs,

Patty

 

If Life hands you lemons, make lemonade.

 

Hashimoto's thyroiditis, Limited scleroderma, Dermatomyositis. Diastolic Dysfunction, dysphagia, Fibro, restless leg. Lupus is a maybe.

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Thanks for the replies,

I have been at this for several years. I just like coming onto the forums every now and again to see if new info. has been learned. I have found over time that I get more info. from the patiences experiences. Plus the info. is more condensed a lot of people a lot of Dr. visits, a lot of shared experiences.

I have had raynauds for about 10 years. This was my first problem. I just keep waiting for science to catch-up with me.I knew then that a positive ANA was not a factor of raynauds but science is full of contradictions.

I have not been tested for an ANA in the past year. My Dr. said I have tested positive enough times. Not in titers reg. 0-99 and I have been in the 500's. My SCL-70 test 0-99 reg. I have tests in the 300's.

I have the usual complaints.

 

Thanks again This seems like a nice place,

em

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Than you for replying.

I am at a junction right now. My doctor relocated. There is no rheumatologist in the area; I would need to travel. So I guess that what brings me back to the "forums".

So just for my clarity. raynauds alone would not produce the positive labs?

My mother also has some sort of autoimmune disease but they cannot give her a clear diagnosis. Due to her age (82) she does have some degenerative joint disease. Her BP is all over the place. She has the other usual complaints very swollen hands, fatigue, cold toes, terrible stiffness at times that can last for weeks. After being on prednisone for a couple of years the one thing that finally gave her some relief is hydroxychloroquine. Also my grandparents were diseased before I was born and Ijust learned my mother's mother died from Brights disease. My mother's labs come back almost normal (go figure).

So now I have to figure out what steps I need to take that is best for me and my family.

I have intestinal issues and high BP along with the previous complaints I stated in my earlier post. It looks like for now I have sine scleroderma with a crossover of lupus. Without skin involvment will the doctor ever really know for sure?

 

Thanks,

em

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em,

A positive raynaud's will not give you a positive scl-70 antibodies or vice-versa.

 

Raynaud's can be caused by a number of things or appear on its own. So many autoimmune illnesses are intertwined and sometimes it is very hard for the doctor to single out just one in order to give you a diagnosis. Sometimes (unfortunatley) we never get a solid "clear-cut" diagnosis. On the other hand that is not always a bad thing. The reason that one gets a diagnosis is because one trait stands out amongst the rest...but a Mixed Connective Tissue Dissorder has a good prognosis, so that is not such a bad place to be either.

 

Hydroxychloroquine (Plaquenil) is a good general medication that can help with several symptoms of autoimmune related issues. It helps with the joint pain, sometimes the stiffness and fatigue.

 

I am sorry to hear that you are just now learning about your family's unfortunate medical background. Just because many of them had an autoimmune dissorder, doesn't meant that everyone in your family will...you may even exhibit the antibodies because it is in your family, but never show any signs of an active illness. Just something to remember.

 

Please stay in touch and let us know how you are doing. If you do find yourself getting worse, it is always worth the travel to the doctor.


*WestCoast*

 

********

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oh sorry, I also forgot to mention I have a low C3. It fluctuates depending on how much joint pain and inflammation my body is dealing with.

em

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Hi Patty,

If you have tested Positive for the SCL-70 test, than why have you been diagnosed with having Limited Scleroderma? :unsure: , I thought that SCL-70 test was for Diffuse?.

 

Many thanks

Celia

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Sorry I didn't get back to you earlier Patty but l do not get on the computer as often as I would like. Life is just too busy. I have a diagnosis of mixed connective tissue disease. I don't think the Dr. knows for sure what kind of scleroderma I have for sure.

I have some COPD, high BP, raynauds, three years ago my hands started swelling and I had some nodules on them,I have constant pain;similar to carpel tunnel syndrome, GI issues, and "toothache " like pains in my knees, wrist, toes and ankles. (This has since improved some) and sicca.

If I over use my voice I will get hoarse. I cannot read a story to my son past about 5 pages because my throat starts to hack constantly even if I drink water. So who knows what's really going on?

But thank you for all that replied to my post,

em

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HI,

I also have a positive for Scl-70 and C-3 complement runs slightly low 74-84 with normal being 90- +.

I have had 2 positive SCL-70 and 3 negative SCL-70 test after the positives.

I have fatigue sometimes, and just weird little things that happen. A little pain that comes and goes

in my back area all over. Everything internally has been looked at. Nothing wrong.

All other labs are good.

Occasionally in the past when I am run down my platelets have dropped below the 150,000 mark.

I am 37 years old and the mother of Twins that are now 5 years old.

I get just a little cold and my hands will turn splochy with White and Red.

I am not sure if it is Raynands, but my hands are never blue.

I am going to my third rheumatologist Sept 2nd, and my third rheumatologist in Oct at Emory.

No clinical symtoms. My friend that is a cardiologist did find just a little extra fluid on my

periocardium 30cc extra. I have 90 cc and normal is 60cc.

Does anyone else have a positive scl-70 and how long?

I am find that the doctors don't understand Scleroderma.

Tonya

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Hi,

How low is your c3-complement? Mine is usually 6-10 points under what is normal.

I think it has to do with how well your body fights off infections.

Tonya

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Hi,

What are the doctors telling you? I am searching for a scleroderma specialist and would like to go to someone that has seen everything.

We do not have one here in Ga. Does anyone know of a great sclero specialist. I have seen this list, but I want names and experiences too.

Referrals for a person is the best. Scl-70 positive and c-3 complement slightly low.

Anyone please give a suggestion. Thank you, TonyainGa

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Hi Patty,

How long have you been positive and no symptoms? If looks like you joined in 06.

I had a positive in 07, and negatives since, but I had a weak moment the other day. I went to

any lab test and ran scl-70, c-3 complement, and thyroid panel because I wanted to check.

I just feel tired which is starting to make me wonder. I am 37 and had to do fertility drugs to get pregnant, and I wonder

if this did not send me in to a spiral since I could not get pregnant.

I took lots of hormones trying to get pregnant.

Anyway, please tell me more about your scl-70 experience? Thank you, Tonya

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