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I'm wondering about the ana. Does it just keep going up and up and does that mean stuff is going on inside, like GI, lungs, heart, kidneys...?

Sorry for posting so many questions, but thanks so much for your answers!!!

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Cordy, welcome to the forums! I have had a high ANA for a while and was told that it only meant that I had increased inflammation. I accepted that explanation as I had swelling of hands, feet and arms. My ANA has been as high as 640 and I have not had sclero affect any organs. I am starting to experience GI issues, but they are mild at the current. My chronic problems are muscular and joint pain (including fibromyalgia), stiffness and fatigue. Now I'm starting to have back issues but don't think it's sclero related.

I may have Scleroderma, but Scleroderma doesn't have me!

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I could be wrong, but I think ANA is like as yes or no question and is not necessarily an indicator of what's going on inside.



You can deprive the body but the soul needs chocolate

my HMO makes me wear a helmet...

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Hi Cordy,

My rheumatologist may be wrong, but she said that the level of ANA does not have a correlation to the severity of your condition.


Hope this helps & GOOD LUCK,


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I found this article on our antibodies page.

Definition of Antinuclear antibody.
It states "ANAs indicate the possible presence of autoimmunity...ANAs are found in patients with a number of autoimmune diseases, such as systemic lupus erythematosus, Sjogren syndrome, rheumatoid arthritis, polymyositis, scleroderma, Hashimoto thyroiditis, juvenile diabetes mellitus, Addison disease, vitiligo, pernicious anemia, glomerulonephritis, and pulmonary fibrosis. "

Mine has stayed stable and was only used to indicate autommune, but nothing else.

Big Hugs,

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi Cordy


I answered to this but in your previous question path....


My family doctor told me that the ANA test is the most unreliable because it can read false which is why they need to rely on other symptoms to diagnose diseases as well (that blood test by itself is not enough to diagnose scleroderma).


I'm not sure what type of ANA you were tested for but my understanding is that the centromere pattern points to System Scleroderma Limited/CREST and the SC1-70 points to Systemic Scleroderma Diffuse. Different patterns can refer to different diseases as far as I know. I read that the normal range for ANA is 1:40, although some say it is 1:60...so anything higher than that should likely be investigated further to see what's going on (ie, autoimmune problem maybe or whatever?).


I could be wrong, but I don't think the ANA itself has anything to do with the internal involvement or joint problems...I think it just points to the type of disease?? I know that I was told there was no need to run that ANA test again on me...even if it changes, because it in itself is not 100% factual anyway. The other symptoms are the pieces really, that's when the puzzle fits (so to speak).


Hope that helps?


I see now that it looks like we are all on the same wavelength...that's it's an indicator of autoimmune diseases only.

Sending good wishes your way!

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