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Scleroderma Causes

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I think my genes and weakening of my whole system when I was stuck in hospital for 10 months with a huge benign growth on my tail bone in my teen years. Right after that fatigue and joint pain started. I strongly believe in the microchomerism theory as well.


I was also thinking whether there is a connection between being born to an older mother (40 +) and genetic defects/mutations favoring the scleroderma phenotype.

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Hiya Razz and all my buddies,


What a very interesting and enlightening thread. My doctor, who does tons of research and goes everywhere in the world for sclero conferences, tells me that there IS some kind of predisposition, they just haven't found it yet. Then something, perhaps a virus we didn't even know we had, triggers it.

In my case I do believe stress was involved. And I was the owner of a ceramic studio and used glazes with silica. Who knows? We have to wonder. My doctor also told me that he has a 'cluster' (his word) of sclero patients who all live in the same neighborhood where I grew up. One day when he has a spare intern he says he'll order a study.


Your posts on dental amalgam also perked up my ears being a dental professional for 20+ years. Everything I have learned tells us that it is better leaving the amalgam in place rather than removing it. All dental offices have to follow very strict guidelines on the disposal of amalgam these days. If you go to a reputable, ethical dental professional you are in good hands. Amalgam removal was a hot buzz in the 90's and we saw a large influx of people who wanted their amalgam removed for various reasons, MS patients, RA patients, etc.


In my years, I have never seen one person whose symptoms have been relieved nor have I heard of or read any studies which confirmed any relief. My boss served as president of the council on dental education so believe me, we were in the loop.


Additionally, my doctors were wary of amalgam removal with no justifiable medical reason, especially since it re-exposes the patient! So yes, if you said you wanted it done for cosmetic reasons, you had to sign an agreement that the treatment was rendered at your request and was not recommended because of decay. Remember dentists have to protect themselves from liability if someone says their amalgam removal made their symptoms worse.


People have enough anxiety about their teeth without making things worse. I personally have amalgam in my mouth and believe it is the best restorative material in some cases where bonded (white) fillings just aren't strong enough.


There will always be controversy surrounding amalgam, and my advice in any situation is to find the best dentist you can and be secure that he or she is well educated and ethical, and follow their advice. Never, ever shop for price where your teeth are concerned. I always want to know where they are 'saving' money and hope it is not in the sterilization area, or patient or staff safety.


Peace out!

Mary in Philly

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Hello All


I've just read some of the newer posts to this topic.


I've not heard of Microchimerism before so just read what it says "refers to the presence of foreign cells in one's body or the harboring a small number of cells or DNA from a genetically different individual". Is this referring to pregnancy or when someone absorbs their twin in utero? I'm now going to check my twin for missing parts, if I've got them she ain't getting them back as revenge for the poor, hapless, naked fashion dolls that fell wounded as a result of our childhood arguments.


Take care.



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I laughed when I read your post, Amanda. I am pretty sure you were just kidding, but just to clarify, I believe microchimerism refers to fetal cells. On the same page Eos linked to (Fetal Cells and Scleroderma) is this article:


Mothers And Offspring Can Share Cells Throughout Life. Cutting the umbilical cord doesn’t necessarily sever the physical link between mother and child. Many cells pass back and forth between the mother and fetus during pregnancy and can be detected in the tissues and organs of both even decades later. ScienceDaily. 05/08/08.


They may never call or write, but somehow they always stay with you! :D

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There is a study of twins where the link of fetal cells passed from one to the other is the possible cause of scleroderma. I'm not sure of the study's name. I find the microchimerism theory very interesting too.




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