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Antiscleroderma-70 antibodies

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My mother has been having joint and hand pains. She recently had a test run (I think the name was Angiotensin-converting enzyme ace test) and found out that her antiscleroderma-70 antibodies level was at 323H.


I have no idea what any of this means. I have tried to Google to get more info and found this forum and hope that someone can provide some insights. Any feedback would be greatly apprecaited!!


If I am not providing enough information to be helpful, please let me know what other information you would need.


Thank you!

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Hello Autigerfaninatl


Welcome to this forum where loads of people have info to share regarding blood test markers and their relevance in relation to diagnosis.


I don't know about the antisclero-70, what I do know is that it takes more than blood work results to rule scleroderma in or out. For example people with scleroderma can be ANA positive and have high positive numbers and feel great. They can have low positive numbers and feel awful. In addition 5% of people with scleroderma have a negative ANA so it's neither high or low and they fair the same as those with a positive result. :blink:


Having looked at this issue myself my personal conclusion is that bloodwork alone means nothing and does not even tie in with how someone is feeling. In the beginning we want factual information the difficulty comes when we realise that the application of the factual information does not necessarily indicate anything or at least what it's supposed to indicate dependant on which doctor you talk. :huh:


Someone will no doubt explain the scl70 to you so you can make up your own mind. Just don't put all your eggs in one basket as a result of one test. ;)


Take care. :lol:



Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

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(Retired) ISN Sclero Forums Assistant Manager

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International Scleroderma Network (ISN)

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Hi, augiterfaninatl


Amanda is right. Here is a link to a recent thread which discusses this test a bit more and also includes some links.




I assume that your mother has seen a rheumatologist who has run the test. Hopefully the rheumatologist will be able to tell you a little more as he or she reviews all the other test data and the clinical observations. I wouldn't panic too much about what you read - much of the information found on line can get pretty scary, especially the older stuff. You can feel comfortable with the information posted on the medical pages linked on this site. In the meantime, welcome to the ISN Sclero Forums. I look forward to getting to know you and your mother better.

Warm wishes,



Carrie Maddoux

(Retired)ISN Sclero Forums Support Specialist

(Retired)ISN Sclero Forums UK Chat Host

International Scleroderma Network (ISN)

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