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Variation of immunological response in methotrexate-induced pneumonitis

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Variation of immunological response in methotrexate-induced pneumonitis (MTX-P).


Our findings suggest that MTX-P can be divided into two groups: type 1 MTX-P that occurs early, predominated by neutrophils, lung fibrosis and has a high mortality; and type 2 MTX-P that occurs late, predominated by lymphocytes, has less lung fibrosis and low mortality. B. Chikura. Rheumatology 2008 47(11):1647-1650. (Also see: Immunosuppresants and Pulmonary Involvement)


This item was posted in the ISN Newsroom. Check the Newsroom every day for the latest scleroderma medical and support information.

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi Janey,


Thanks for the info. It has always made me very nervous taking methotrexate and for such a long period of time. I have taken it for 7 or 8 years (give or take). I am always asking if this or that problem is related to the methotrexate. It is suspect to me for anything that happens. The dermatologist included drug toxicity in the last skin biopsy and it was negative. The pulmonologist said she would see drug toxicity on the PFT's. The rheumatologist said she would see changes in the cbc, chemistry and liver panels. It scares me as much as systemic sclerosis. My skin is such a mess without it and so is the pain. Not sure what effect it has with pain but my immune system is kept in check and symptoms have been kept to a minimum except for recently which are basically new symptoms or exacerated old ones for me or maybe the scleroderma has become extremely pushy. Don't know; don't like to play in traffic but the other treatments did not work. I wish there were better options instead of such toxic ones.


Thanks again Janey.


With gentle thoughts,



A happy heart is good medicine.

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