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Jenn NJ

New to Board - Question on RNP blood work

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I'm new to the board.

I have not been diagnosed with anything yet, but have been undergoing testing due to a painful reddish "bruise" above my right breast. After testing to rule out IBC, I had blood work done.

The results were normal except that my RNP antibodies were 130. I have an appt with a Rheumatologist to explore further, but I would like to know what I could be looking at. I see MCTD, etc - but I don't know what that is or does. I'm not looking for a board diagnosis - just some ideas or areas to research. I'm quite clueless and have no idea what any of this is.

I noticed another woman's posting who had a 102 count. What is considered normal range, and am I very high? This is all very confusing.

Thank you in advance,


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Welcome to the ISN forums. Sorry to that you are having to go through the "difficult diagnosis" process; however, it does sound like you have at least one doctor that is trying to help you find out what is really going on. As far as the RNP is concerned, I don't know what is considered normal; however, on our mixed connective tissue disease page it does state that a high RNP (ribonucleoprotein) is associated with mixed connective tissue disease (MCTD). MCTD is normally defined as " Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus ertythematosus, systemic sclerosis, and polymyositis" (ISN). However, sometimes it is also used when a patient has two or more of any of the connective tissue diseases (CTD).


So in answer to your where do I start question, I would suggest starting with our MCTD page and go from there. This page will take you to various medical sites that will provide much more information. Just click on the above link.


I hope you find some answers. Please keep us informed.


Big Hugs to you Darlin',

Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi Jenn,


Welcome to the Forum.


It's tough to be at the "I might have something, but what??" stage~ I did a wonderful job of scaring myself to death. :lol:


Have you looked at the page on MCTD? There is information on that page about MCTD and also about anti-body levels.


I know that when I had my first appointment with the rheumatologist who made the diagnosis and he was reviewing the various test results with me, he made the comment about my "always impressive antibodies" which were up around 1200 at that time (ANA with nucleolar pattern).


It can be very confusing and sometimes scary when you are in the pre-diagnosis stage, but it sounds like you're on track with an appointment to see a rheumatologist for further investigation.


Warm wishes,

Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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Janey and Jeannie have both given you good links. I have nothing to add except for warm hugs and a big welcome to the forums. I look forward to getting to know you better.

Warm wishes,



Carrie Maddoux

(Retired)ISN Sclero Forums Support Specialist

(Retired)ISN Sclero Forums UK Chat Host

International Scleroderma Network (ISN)

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Jenn NY,


Welcome to the forums. I'm not familiar with the RNP test, but there are many knowledgable people who post that may be able to share their thoughts with you. When I was in the "What do I have stage" I found a site that listed many of the blood tests and it also told you why they are commonly ordered and what the test results will tell the ordering physician. I'm naming it in the post, but in the event that's not allowed and it's omitted send me a PM and I'll send it you.


Best wishes!!

I may have Scleroderma, but Scleroderma doesn't have me!

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Hello Jenn


Welcome and hello!


I can't add to what's already been said info wise, however, wanted to suggest that you don't take what you read on the internet (apart from this site) too seriously. You don't yet have a diagnosis and a lot of the stuff can be worse case scenario, all doom and gloom.


There's so much information but only some of it will apply to you and until you get a diagnosis it's hard to determine what info to absorb and what to disregard. Mind you even with a diagnosis there's no certainty about how a disease will progress!


You'll always get good info here based on experience and accurate up to date material.


Take care.



Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

ISN Video Presentations Manager

ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist

International Scleroderma Network (ISN)

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