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Amanda Thorpe

Amitriptyline: How was it for you?

14 posts in this topic

Hello All

 

Yes it's me again I am being greedy with 2 posts at once. :)

 

I have been taking amitriptyline for about a week 10mg morning and evening for pain. Apart from a few days of being mega irritated I don't think I have had any side effects although my erythromyalgia (EM) is worse at present but I don't know if that's coincidental. I discovered in some old posts (searching for a friend re: Raynaud's) that some people found them intolerable.

 

My questions are

 

1) How long before you got the full effect?

2) What side effects and did they go?

3) Did it improve your mood?

 

Thank you in advance and anything else you want to share about your amitriptyline experience is greatly received.

 

Take care.

 

Amanda


Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

ISN Video Presentations Manager

ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist

International Scleroderma Network (ISN)

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Hi Amanda,

 

I took Ami for awhile and I could not tolerate it at all. It made me so sleepy I could not function at all during the day even though I took it at night.

 

It's possible that I may have done better with a smaller dosage but I just wanted off of it. I don't remember any benefits at all for me. But, that's me. I'm sure others have had positive results.


Take care,

Barefut

 

Serena Justis

ISN Blogger

International Scleroderma Network (ISN)

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Hello Serena

 

Yes the tiredness is an issue. It's good in that it helps me sleep but bad in that it's even harder to get up these days that normal!

 

I think it might be helping with the migraines though, not with frequency but severity. Had one last week and have one now and it's not as bad as usual and last week normal pain meds contained it. Mind you I am supposed to be taking it for nerve pain and I don't know if it's helping this as I am still taking other pain meds. The idea is to phase them out and the ami in.

 

We shall see what happens! :)

 

Take care.

 

Amanda


Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

ISN Video Presentations Manager

ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist

International Scleroderma Network (ISN)

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Amanda I have been taking amitriptyline for awhile, just 25 mg in the evening. I began with 10 mg and was taking that for about 2 months before my general practitioner upped it to the 25 mg. I found it took about 2 - 3 months to settle properly with it and it did help with my sleep. I did find it hard to wake up in the morning but that also gets easier, I know some people find it better to take it earlier in the evening but I always take mine about 1/2 hour before going to bed.

 

Side effects made my mouth even drier and gave me some hot flushes but those settled after a while. It's not made my erythromyalgia (EM) any worse.

 

Taking it has helped some of the nerve pain that I suffer from and it certainly helped me to feel much calmer and lifted my mood, I don't get as upset as quickly and just seem to deal with things much better. For me I think it was the fact I was beginning to sleep at night and because it eased my aches and pains (I used to only get a couple of hours sleep before I started taking them.)

 

Jensue

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Hi Amanda, i've taken amitryptilline for about 5 years for migraine prevention. I started at 10mg a day and gradually increased to 25-50mg (Dr leaves it up to me to decide whether to take 25 or 50mg) - always at bedtime. Initially felt a bit dozy and hung over in the morning but soon got used to it and feel fine now. In fact probably brighter than I used to because It really does help me to sleep. As Jensue says , it does make my mouth dry , so always have water next to the bed. Re effect on mood- i'm really not sure, I think maybe at the higher dose ( 50mg) it might , but even that is a lower dose than would generally be given for mood disorders. All I can say is that I have always been a generally cheerful person and don't feel any different, but maybe if I stopped taking I would. Now that my migraine has improved so much I keep thinking I should stop taking it - but am reluctant as really does make a difference to my sleep. Also the rheumatologist said that it should help with skin itching /burning (although not convivnced myself).

 

Lizzie

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Thanks Jensue and Lizzie, I forgot about the dry mouth particularly at night.

 

I wonder if I should just take 20mg at night as opposed to a split dose? Unfortunately my general practitioner made no comment on dosage as the rheumatologist recommended it so I'm making it up as I go along.

 

Although I want it for nerve pain my main aim at present is to eliminate/radically reduce the migraine. Lizzie, how long were you on it before it effected the migraines and how long did it take to build up the dosage?

 

I do consider myself to be a happy/laugh a lot person but even I get laid low (mood) by sclero so I wondered if a bonus side effect (must be one out there) might be improved mood. Jensue you mentioned you have more tolerance and this has always been something I could do with more of! :lol:

 

Happy days! -- as my sister's boyfriend always says mind you he's mad as a hatter and not just because he is dating my sister and by the way her butt is bigger than mine...she doesn't read this site, pity.

 

Amanda


Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

ISN Video Presentations Manager

ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist

International Scleroderma Network (ISN)

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Hey Amanda

 

I'm on 10mg night and have been for many years (I think about 10 years or so?). I take it for headaches, helps greatly -- still get some of course, but not as severe or as often and can now control those I do get with tylenol. It definitely makes you sleepy. I take mine at bedtime only as ordered by my doctor. If I'm not mistaken my pharmacist said the same thing to me because of the grogginess it can cause. I don't have any side affects from it but Ihave heard that some people have big weight gain with it though (a friend of a gal I work with gained 30 lbs on it). Since they didn't instruct you otherwise, and you're testing on your own it might be an idea to consider night time only, unless of course, you're not adverse to sleeping all day and all night ;) . Keep us updated on how it works for you!


Sending good wishes your way!

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Hi again Amanda, From what I remember it strated to help with the Migraine after a few weeks. Didn't eradicate them but certainly seemed to have fewer. They have got much better recently and I put it down to in part the treatment for raynauds and in part to no longer having periods - always used to get them pre-menstrually. What has revolutionised my life re the migarines though is Sumatriptan prescribed by my general practitioner- taken as soon as I feel the familiar wieredness, tiredness, and one sided headache and sneezing ( yes- i always sneeze when one is starting!), it stops it progressing 9 times out of 10- is my hero drug! Only downside is that exacerbates the raynauds when I take it -but is worth it!

 

Lizzie

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I did used to get headaches very frequently which where very bad but since taking the amitriptyline I rarely get any. But I put that down to the fact I wasn't as stressed because of work and the of lack of sleep. It is so good having a good sleep, somedays I don't get up until 8.00 am which was unheard of for me before I took them!

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Hi Amanda,

 

I was on amitryptyline for a while and just couldn't stand it. I had horribly vivid nightmares, anxiety, and a feeling that I could only describe as what I thought going crazy would be like. It didn't do anywhere near enough for my pain levels to make it worth while.

 

Hugs,


Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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Hi,

 

I took amitriptyline last year for about 5 months to prevent headaches. It did not work, and it made me gain a lot of water weight, about 3 dress sizes and I just felt so bloated all the time. Once I went off it the weight went off within weeks, without trying!

 

So for me, no effect but not-so-great side effect.

 

Good luck.

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Hi, I've been on amytriptylene and also atenolol (for fast heart) for a few years now and the combination of the two has really helped with my migraines. The only time I get one now is when I try to go off of the amytriptylene. I think it also helps my pain levels and I sleep better. I have gained over 20 lbs since I started taking them though. The atenolol causes my raynauds to be worse so I guess you have to weight the pros and cons of any drug you take. For me, not having migraines is worth the weight gain and sluggishness.

Take care,

Hugs, Piper

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Hello All

 

Jeannie I also have mega vivid dreams now! I told my husband of one I had the other day because it was totally weird..it was like being in a disaster movie but the stragest thing was that at the end of the dream, like the end of these movies, I went to look in the group of "survivours" for my hubby and there he was BUT bearing in mind it's an amytriptiline fuelled dream the "survivours" were the content of my make up case all in the bath and I picked up my favourite red lip pencil overjoyed because that was my husband :lol:! Let me just wave bye bye as I make my way to the funny farm.

 

Piper, I'm with you if it works for the migraines any weight gain will be worth it.

 

Eos, sorry it didn't help and glad the weight just came off, what a bonus.

 

Amanda


Amanda Thorpe

ISN Sclero Forums Senior Support Specialist

ISN Video Presentations Manager

ISN Blogger

(Retired) ISN Sclero Forums Assistant Manager

(Retired) ISN Email Support Specialist

International Scleroderma Network (ISN)

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I have been on amitriptyline(Endep) now since being diagnosed 2 years ago. My rheumatologist put me on it for depression ,as well as having fibromyalgia. Before being on it I could sleep 10 hours a night and still wake up feeling exhausted. I wasn't getting that deep sleep that you need to feel refreshed in the morning. I started off on 12.5mg in the evening, and was told to take it approx 2 hours before going to bed. It has now increased to 75mg still in the evening as my mood was going down hill and I felt that I was terribly bruised in the chest, which is fibromyalgia pain. It has helped me alot, with the pain and the depression, and I now wake up feeling refreshed. I still need though about 10 hours a night to sleep or I would feel like a zombie the next morning.

 

I tried to come off it suddenly awhile back, it was terrible, I had hallucinations at night and would wake up suddenly seeing all sorts of weird things. My problem was because I felt so good being on it, I thought I could live without it. Big mistake, I felt as low as I could go, I decided to go back on it and am now ok. When I went back on it, the dry mouth and throat disappeared, and I have no side effects now.

 

Summer

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