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janet905

Campath

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hi everyone,

has anyone heard info on campath? new drug. read a small article about it few days ago. mainly used for a specific type of lymphocytic leukemia but is also being used for some autoimmune diseases such as ms. sounds sort of interesting. was wondering if any of you who see the sclero experts had heard of it being tried with sclero.

janet

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Janet,

I found a link which provided some information and there seems to be a lot of reasons not to use it.

My dr told me not to worry if the cellcept stopped working as well as it is now, due to the fact that there are some new drugs either on the market or on the way, but he didn't give any more specifics than that. When I first started cellcept, my insurance co. questioned it, but the doctor gave them good info and they approved it. It is expensive, about $700 a month. Thank goodness for insurance. smile.gif
~whirlway

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Hi Janet--

 

Campath is a monoclonal antibody. Which means it's genetically engineered human antibody that targets immune cells. It is not chemo like cell cept or cyclophosphamide. But it works to do the same thing, destroy T cells and B cells and other immune system cells.

 

From what I know Campath is pretty strong in that it broadly destroys much of the immune system.

 

Take a look at Rituxan it's much less toxic (also a Mab) it targets just b cells and has had success with Rheumatic diseases and autoimmune disease too.

 

From what I've read the whole idea of targeted immune therapy holds a great deal of promise, especially the monoclonal antibody research.

 

Again, not a doctor or researcher here but Campath has been around for over 10 years and has been used for many autoimmune diseases, but it has not caught on and I suspect that is because it comes with a host of problematic aspects. One of which I read about was it can cause secondary autoimmune diseases to manifest.

 

Also it can leave the patient severely immunocompromised and susceptible to severe infections.

 

But its worth reading about. I find the pubmed.com (with the help of a medical dictionary) to be a really good source for finding out how things work and if they hold any promise. Why not see the results for yourself right?

 

Michael in Florida

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Hey Guys,
Based on Janet's posting we did a little research into Campath and now have a section you might be interested in reading. Go to Biologic agents, then scroll down to Alemtuzumab (Campath)

 

There is an article on using biologic agents such as campath for diseases that they are not designed for. This article is followed by a FDA alert and a listing of Campath's side effects. I couldn't find any study since 1999 in which Campath has been used for scleroderma, so there's nothing out there that I could find showing it to be beneficial or not for sclero. There were a couple of studies back in the late 90's, but nothing since.

It is being used along with Cytoxan and Fludarabine in the clinicial trial Allogeneic Hematopoietic stem cells for SSc. In this study it's described as "a protein that kills the immune cells that are thought to be causing the disease".

It will be interesting to see if more is done with it.

Big Hugs,


Janey Willis

ISN Support Specialist

(Retired) ISN Assistant Webmaster

(Retired) ISN News Director

(Retired) ISN Technical Writer for Training Manuals

International Scleroderma Network (ISN)

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Hi Janey,

 

Thank you so much for this GREAT information and for taking the time to find this information for us!! You are the greatest.

 

Warm wishes,

Heidi

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