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TH/TO Antibody

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I am positive antibody th/to. I just read that this antibody has a poor prognosis along with severe lung disease. No surprise about the severe lung disease, but has anyone else read that it has a poor prognosis? Four years of research and this is the first time I have read this.




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Hi Clementine,


As it happens, we have an article on TH/TO and pulmonary fibrosis:


Anti-Th/To-Positivity in a Cohort of Patients with Idiopathic Pulmonary Fibrosis. Our findings indicate that a nucleolar-staining ANA is a common finding in patients with IPF, and that antibodies against Th/To are responsible for the majority of these. The Journal of Rheumatology. Vol 33: NO. 8 Aug 2006.


Aren't you surprised? :D


From this article and a review of what is out on the web, it looks to me that testing positive for these antibodies is more of a diagnostic tool than a prognostic one. For instance, when people are diagnosed with idiopathic pulmonary fibrosis (idiopathic = unknown cause), a positive TH/TO would cause a doctor to look more closely towards systemic sclerosis as the underlying cause of the pulmonary fibrosis. I haven't read anything about it being an indicator of a poor prognosis either, which is not to say some researcher may feel that it is.


No matter what you read, you always have to remember that these articles can never give you your prognosis. There are literally zillions of variables and each of us will have a unique progression (or lack of progression).


Big hugs,

Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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