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Calcinosis Cutis

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Hello everyone, I was searching on the internet and found an interesting Japanese study on Probenecid therapy that has proved to help decrease Calcinosis cutis. And I just would like to know if any of you have heard of this therapy.


Warm regards



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Hi Alice,


We do have mention of Probenecid in the articles in the section on Calcinosis, specifically in this one:


Calcinosis in rheumatic diseases. While warfarin, colchicine, probenecid, bisphosphonates, diltiazem, minocycline, aluminum hydroxide, salicylate, surgical extirpation, and carbon dioxide laser therapies have been used, no treatment has convincingly prevented or reduced calcinosis. However, the approach to calcinosis management is disorganized, beginning with the lack of a generally accepted classification and continuing with a lack of systematic study and clinical therapeutic trials. PubMed. Semin Arthritis rheumatologist. 2005 Jun;34(6):805-12


That isn't a very encouraging article, but at least the authors are aware of the lack of attention being paid to the problem. Hopefully there are studies that will have positive results and


Best wishes,



Jeannie McClelland

(Retired) ISN Director of Support Services

(Retired) ISN Sclero Forums Manager

(Retired) ISN Blog Manager

(Retired) ISN Assistant News Guide

(Retired) ISN Artist

International Scleroderma Network

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