Joint production of IL-22 participates in the initial phase of antigen-induced arthritis (AIA) through IL-1ß production. These results suggest that IL-22 plays a pro-inflammatory/pathogenic role in the onset of AIA through an Antibody Secreting Cells-dependent stimulation of IL-1ß production. Arthritis Research & Therapy, 09/02/2015. (Also see Causes of Rheumatoid Arthritis and Interleukins)
Rituximab Safe for Up to 11 Years in Rheumatoid Arthritis (RA). Rituximab had a consistent safety profile through multiple courses used in treating (RA) during 11 years of observation and was not associated with excess infection rates, cardiac events, or malignancies. Medscape, 09/01/2015. (Also see Treatments for Rheumatoid Arthritis and Biologic Agents)
Main causes and risk factors for hospitalisation in patients with primary Sjögren's syndrome. The major causes for hospitalisation were disease activity and infection and patients with hepatic involvement, vasculitis and more damage accrual had the highest risk for being hospitalised. PubMed, Clin Exp Rheumatol, 08/27/2015. (Also see Symptoms and Complications of Sjögren's Syndrome)
The efficacy of tacrolimus in patients with refractory dermatomyositis/polymyositis (DM/PM): a systematic review. Current evidence appears to support the use of tacrolimus in refractory PM/DM and PM/DM-ILD patients and it seems to be a safe drug that improves both muscle strength and lung function, and is well tolerated by patients. PubMed, Clin Rheumatol, 09/02/2015. (Also see Treatments for Dermatomyositis and Polymyositis)
Prevalence and clinical impact of fibromyalgia (FM) in patients with primary Sjögren's syndrome (pSS). The study showed that FM was prevalent in pSS and FM was associated with higher EULAR Sjögren's Syndrome Patient Reported Index and more severe depression. PubMed, Clin Exp Rheumatol, 08/27/2015. (Also see Fibromyalgia and Symptoms and Complications of Sjögren's Syndrome)
Pathogenesis and targeted treatment of skin injury in systemic lupus erythematosus (SLE). Ultraviolet light (UV), immune cells, cytokines and deposition of immunoglobulins all seem to have a role in the development of skin inflammation and damage in SLE. PubMed, Nat Rev Rheumatol, 08/04/2015. (Also see Symptoms and Complications of Lupus)
How are cancer and connective tissue diseases (CTDs) related to sarcoidosis? The association between sarcoidosis and both cancer and CTDs may yield important insights into the immunopathogenesis of all three diseases. PubMed, Curr Opin Pulm Med, 2015 Sep;21(5):517-24. (Also see Connective Tissue Disease, Sarcoidosis and Cancer)
Finger stiffness or edema as presenting symptoms of eosinophilic fasciitis. Finger symptoms of patients with EF might be caused by fasciitis of the forearms, which leads to dysfunction of the long finger flexors and extensors as well as slight edema of hands. PubMed, Rheumatol Int, 08/07/2015. (Also see Eosinophilic Fasciitis)
Myositis Mimics. Some of the most common acquired and inherited muscle diseases that can mimic autoimmune myositis are reviewed. PubMed, Curr Rheumatol Rep, 2015 Oct;17(10):541. (Also see Myopathy and Myositis)
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