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October 2016 Autoimmune News

The clinical spectrum of Medium-sized Vessel Vasculitis. Systemic polyarteritis nodosa, cutaneous arteritis and gastrointestinal vasculitis demonstrate different clinical courses and therefore may be different diseases rather than a spectrum of the same disease. PubMed, Arthritis Care Res (Hoboken), 08/26/2016. (Also see Vasculitis)

Comorbidities in patients with Primary Sjögren's Syndrome (pSS) and Systemic Lupus Erythematosus (SLE): A comparative registries–based study. pSS patients have consistently less serious cardiovascular comorbidity burden and a lower prevalence of severe infection than those with SLE, although in contrast, their risk of lymphoma was greater. PubMed, Arthritis Care Res (Hoboken), 08/26/2016. (Also see Sjögren's Syndrome and Lupus in Overlap and Complications)

Factors Associated with Sustained Remission in Rheumatoid Arthritis in Patients Treated with Anti–Tumour Necrosis Factor (anti–TNF). Evidence identified in this review supports current recommendations for methotrexate co–prescription and highlights the negative impact of particular clinical and demographic features on the likelihood of achieving optimal response to anti–TNF treatment. PubMed, Arthritis Care Res (Hoboken), 08/26/2016. (Also see Treatments for Rheumatoid Arthritis)

Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. Contrast–enhanced ultrasound molecular imaging can detect endothelial inflammation and leukocyte infiltration in myocarditis and imaging of CD4+ T cells involved in autoimmune responses could be helpful in diagnosing it. PubMed, Circ Cardiovasc Imaging, 2016 Aug;9(8). (Also see Cardiac (Heart) Involvement)

Low levels of calcium or vitamin D, which is more important in systemic lupus erythematosus patients? An extensive data analysis. Calcium levels may play a significant role in the SLE disease process, more than originally thought, since SLE patients are at a higher risk for hypocalcaemic events. Clinical and Experimental Rheumatology Online, 09/01/2016. (Also see Vitamin D Deficiency and Research on Systemic Lupus Erythematosus)

Prognostic significance of platelet count in SLE patients. It was concluded that platelet count has a negative correlation with disease activity in SLE patients, and it should be considered as a prognostic factor, identifying patients with aggressive disease course. PubMed, Platelets, 2016 Sep 2:1-5. (Also see Symptoms and Complications of Lupus)

Impact of heart rate variability (HRV), a marker for cardiac health, on lupus disease activity. Impaired HRV, particularly the low frequency to high frequency ratio, is associated with lupus disease activity and several cytokines related to interferons type II and tumor necrosis factor pathways. PubMed, Arthritis Res Ther, 2016 Sep 2;18(1):197. (Also see Symptoms and Complications of Lupus)

Recent Advances in Autoimmune Thyroid Diseases. In this review, focus is on recent advances in understanding the genetic and environmental pathogenic mechanisms underlying AITD and introduce the updated set of clinical guidelines for AITD management. PubMed, Endocrinol Metab (Seoul), 08/26/2016. (Also see Thyroid Diseases)

The role of TNFα induced protein 3 interacting protein 1(TNIP1) in the pathogenesis of myasthenia gravis among patients with thymoma. Reduced TNIP1 expression may have a role in the pathogenesis of MG for patients with thymoma and thymectomy may help to recover the expression of TNIP1 among such patients. PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2016 Oct;33(5):615-8. (Also see Myasthenia Gravis)

Vascular stiffness mechanoactivates YAP/TAZ–dependent glutaminolysis to drive pulmonary hypertension. These results indicate that extracellular matrix stiffening sustains vascular cell growth and migration through YAP/TAZ-dependent glutaminolysis and anaplerosis, and thereby link mechanical stimuli to dysregulated vascular metabolism. PubMed, J Clin Invest, 2016 Sep 1;126(9):3313-35. (Also see Vascular Involvement)

Go to Autoimmune News: September 2016

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