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February 2017 Autoimmune News

Autoimmunity as a trigger for structural bone damage in rheumatoid arthritis. At present, rheumatoid factor and antibodies recognizing citrullinated proteins are considered as potent osteoclast inducers and triggers for bone loss in arthritis. PubMed, Mod Rheumatol, 2017 Jan 9:1-5. (Also see Diagnosis of Rheumatoid Arthritis)

Serum level of DNase1l3 in patients with dermatomyositis/polymyositis (DM/PM), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and its association with disease activity. A significant reduction was found in serum DNase1l3 level in DM/PM and SLE, which may associate with clinic features and disease activity. PubMed, Clin Exp Med, 12/30/2016. (Also see Dermatomyositis and Polymyositis, Research on Systemic Lupus Erythematosus and Causes of Rheumatoid Arthritis)

Serum Interleukin-34 Levels Are Elevated in Patients with Systemic Lupus Erythematosus (SLE). Serum IL-34 could be a candidate biomarker for SLE as there are elevated serum levels in treatment–naive SLE patients and a significant decrease after effective treatment was seen. PubMed, Molecules, 2016 Dec 28;22(1). (Also see Diagnosis of Lupus)

Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome (PSS). Physical, but not sedentary, activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. PubMed, Rheumatol Int, 12/24/2016. (Also see Sjögren's Syndrome)

Oral to subcutaneous (SC) methotrexate (MTX) dose–conversion strategy in the treatment of rheumatoid arthritis. SC administration provided higher exposure of MTX than the same dose given orally. PubMed, Rheumatol Int, 12/23/2016. (Also see Treatments for Rheumatoid Arthritis)

Value of non–identified ANCA (non–PR3, non–MPO) in the diagnosis of granulomatosis with polyangiitis (GPA) (formerly Wegener's granulomatosis). GPA with non–MPO, non–PR3 ANCAs is relatively rare and our study suggests that GPA with nonidentified ANCA differs from GPA with identified ANCA by the frequency of localized forms. PubMed, Acta Clin Belg, 2017 Jan 9:1-5. (Also see Granulomatosis with Polyangiitis)

Paediatric anti–neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV): an update on renal management. The aim of this article is to provide a comprehensive review of paediatric AAV, with a focus on renal manifestations, and to highlight the recent advances made in therapeutic management. PubMed, Pediatr Nephrol, 01/07/2017. (Also see Vasculitis)

Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group Diagnostic Criteria as a Chronic Ocular GVHD–Specific Metric. The newly proposed International Chronic Ocular GVHD Consensus Group diagnostic criteria can be used reproducibly for the diagnosis and determination of severity of chronic ocular GVHD. PubMed, Cornea, 2017 Feb;36(2):258-263. (Also see Graft-versus-Host Disease)

Diagnostic and therapeutic strategy in Ménière's disease. Therapy comprises medical treatment and surgery, either conservative or sacrificing vestibular function. PubMed, Eur Ann Otorhinolaryngol Head Neck Dis, 01/03/2017. (Also see Autoimmune Ear Diseases)

Protective personality traits: High openness and low neuroticism linked to better memory in multiple sclerosis (MS). Personality may inform predictive models of memory impairment in MS. PubMed, Mult Scler, 2017 Jan 1:1352458516685417. (Also see Multiple Sclerosis)

Go to Autoimmune News: January 2017

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