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March 2017 Autoimmune News

Comparative Rates of Serious Infections Among Patients With Systemic Lupus Erythematosus (SLE) Receiving Immunosuppressive Medications. In a nationwide longitudinal study of Medicaid SLE patients at high risk of infection, rates of serious infection and mortality did not differ among new users of mycophenolate mofetil, azathioprine, or cyclophosphamide. PubMed, Arthritis Rheumatol, 2017 Feb;69(2):387-397. (Also see Treatments for Lupus)

Identification of treatment responders based on multiple longitudinal outcomes with applications to multiple sclerosis patients. Our simulation study shows that incorporating multiple outcomes improves the responder identification performance; this can occur even if some of the outcomes are ineffective. PubMed, Stat Med,02/01/2017. (Also see Multiple Sclerosis)

Pain extent is associated with pain intensity but not with widespread pressure or thermal pain sensitivity in women with fibromyalgia (FMS) syndrome. Pain drawings constitute an easy and accurate approach to quantify widespread pain and larger pain extent is associated with pain intensity but not with signs of central sensitization in women with FMS. PubMed, Clin Rheumatol, 02/04/2017. (Also see Fibromyalgia)

Case Report: Early diagnosis of early–onset sarcoidosis (EOS) with functional analysis and review of the literature. Skin rash with granuloma formation and specific NOD2 mutations may represent early diagnostic hallmarks of EOS in infants with persistent inflammation. PubMed, Clin Rheumatol. (Also see Sarcoidosis)

Comparison of different enzyme–linked immunosorbent assay methods for avidity determination of antiphospholipid antibodies. Both urea and sodium chloride may be used as chaotropic agents and reference values of avidity indices essential for interpretation of patients' results must be established individually for distinct assay conditions. PubMed, J Clin Lab Anal, 01/26/2017. (Also see Antiphospholipid Syndrome)

Short–course tocilizumab (TCZ) increases risk of hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis: a prospective clinical observation. To identify the exact risk of TCZ on HBV infection and the prognosis of TCZ–related HBV reactivation, further studies with larger sample sizes and fewer confounding factors are needed. PubMed, Int J Rheum Dis, 02/03/2017. (Also see Rheumatoid Arthritis in Overlap, Clinical Trials and Liver Involvement)

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia (FMS) Patients. In FMS patients, serum IGF-1 levels may decrease due to age and PSQI; however, this may not be related to the severity of obstructive sleep apnea. Archives of Rheumatology, 02/10/2017. (Also see Fibromyalgia and Sleep Apnea and Associated Diseases)

Risk of Myocardial Infarction and Stroke in Newly Diagnosed Systemic Lupus Erythematosus: A General Population-Based Study. Patients with SLE have an increased risk of cardiovascular events, particularly during the first year after diagnosis. PubMed, Arthritis Care Res (Hoboken), 01/27/2017. (Also see Symptoms and Complications of Lupus)

Eighteen Months of Treatment With Subcutaneous Abaloparatide (ABL-SC) Followed by 6 Months of Treatment With Alendronate in Postmenopausal Women With Osteoporosis. Use of ABL-SC for 18 months followed by ALN for 6 months improved bone mineral density and reduced fracture risk throughout the skeleton and may be an effective treatment option for postmenopausal women with osteoporosis. PubMed, Mayo Clin Proc, 2017 Feb;92(2):200-210. (Also see Osteoporosis)

Case Report: Systemic lupus erythematosus (SLE) presenting as severe alveolar hypoventilation and the shrinking lung syndrome (SLS). The interesting features of this case report consist of the presentation of the SLS as an alveolar hypoventilation with a fatal outcome and the presentation of systemic lupus as SLS. PubMed, Rev Mal Respir. (Also see Symptoms and Complications of Lupus and Lung Involvement)

Go to Autoimmune News: February 2017

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