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September 2017 Autoimmune News

Dominant B cell receptor (BCR) clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis. Dominant BCR clones in peripheral blood predict onset of clinical signs and symptoms of RA in at–risk individuals with high accuracy. PubMed, Ann Rheum Dis, 08/08/2017. (Also see B Cells and T Cells)

Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta–analysis. This meta–analysis was conducted to examine the associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis. PubMed, Rheumatol Int, 08/10/2017. (Also see Causes of Rheumatoid Arthritis)

Current concepts regarding calcium metabolism and bone health in sarcoidosis. Vitamin D supplementation may be withheld in sarcoidosis patients with bone fragility, unless calcitriol levels are below normal limits. PubMed, Curr Opin Pulm Med, 2017 Sep;23(5):476-481. (Also see Sarcoidosis)

Symptoms of chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) are not determined by activity pacing when measured by the chronic pain coping inventory. Activity pacing does not appear to be a significant determinant of pain, fatigue or disability in people with CFS/ME when measured with the chronic pain coping index. Physiotherapy, 08/10/2017. (Also see Chronic Fatigue Syndrome)

Relevance of ultrasonography in assessing disease activity in patients with idiopathic inflammatory myopathies. A mixture of muscle edema and atrophy was detected depending on disease activity and duration. PubMed, Int J Rheum Dis, 08/07/2017. (Also see Myopathy and Myositis)

Clinical manifestations of Behçet’s disease (BD) depending on sex and age: results from Japanese nationwide registration. We showed that clinical phenotype in early phase of BD was different depending on onset age and sex. Rheumatology, 08/08/2017. (Also see Behçet's Disease)

The current therapeutic options for Crohn's disease (CD): from medical therapy to intestinal transplantation. CD treatment is mainly medical, leaving endoscopy and surgery for a complex course. PubMed, Expert Rev Gastroenterol Hepatol, 08/14/2017. (Also see Inflammatory Bowel Disease)

Lupus nephritis and B–cell targeting therapy. The combination of different targeted approaches as well as a focus on new clinical end–points may be strategies to identify new therapeutic options. PubMed, Expert Rev Clin Immunol, 08/11/2017. (Also see Treatments for Lupus and B Cells and T Cells)

Immune complexes containing serum B-cell activating factor (BAFF) and immunoglobulin G (IgG) correlate with disease activity in systemic lupus erythematosus (SLE). BAFF–IgG complexes strongly correlate with disease activity in SLE patients, suggesting a pathogenic role in SLE. Nephrology Dialysis Transplantation, 08/08/2017. (Also see Causes of Lupus)

Progress in genetic research on psoriatic arthritis. These studies have laid a foundation for risk prediction, diagnosis and drug development for psoriatic arthritis. PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2017 Aug 10;34(4):606-610. (Also see Psoriasis and Psoriatic Arthritis)

Go to Autoimmune News: August 2017

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