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March 2018 Autoimmune News

Depression and fatigue in multiple sclerosis (MS): Relation to exposure to violence and cerebrospinal fluid (CSF) immunomarkers. The aim of this study was to examine the relationships between depression, fatigue, and exposure to violence, with IL-6 and IL-8 levels in the CSF of MS patients. PubMed, Psychoneuroendocrinology, 2018 Jan 4;89:53-58. (Also see Multiple Sclerosis, Depression and Fatigue)

The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA–Associated Vasculitis. In patients with ANCA–associated vasculitis and kidney involvement who achieve remission after induction therapy, the presence of persistent hematuria, but not proteinuria, is a significant predictor of future renal relapse. PubMed, Clin J Am Soc Nephrol, 01/25/2018. (Also see Vasculitis)

Long–term disease and patient–reported outcomes of a continuous treat–to–target (T2T) approach in patients with early rheumatoid arthritis in daily clinical practice. Continuous application of T2T in real–life RA patients leads to favourable disease–related and patient–related outcomes. PubMed, Clin Rheumatol, 02/01/2018. (Also see Treatments for Rheumatoid Arthritis)

The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement (RDwCNS) from multiple sclerosis. Considering the high specificity of MRZR-2 for MS found in this study, MRZR-2 can be a useful diagnostic tool for distinguishing MS from RDwCNS or other inflammatory neurological diseases. PubMed, BMC Neurol, 2018 Jan 31;18(1):14. (Also see Multiple Sclerosis)

Circulating prolactin levels and Behçet's disease: A meta–analysis. This meta–analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls. PubMed, Cell Mol Biol (Noisy-le-grand), 2018 Jan 31;64(1):14-18. (Also see Behçet's Disease)

Associations between vitamin D receptor polymorphisms and susceptibility to Behçet's disease: A meta–analysis. This meta–analysis demonstrated the association between FokI and ApaI polymorphisms in VDR gene with the risk of BD. PubMed, Immunol Invest, 2018 Feb 1:1-14. (Also see Behçet's Disease and Vitamin D Deficiency)

Endobronchial Mucosal Neuroma with Sarcoidosis. A first case of endobronchial mucosal neuroma with sarcoidosis is hereby reported. PubMed, J Coll Physicians Surg Pak, 2018 Feb;28(2):162-163. (Also see Sarcoidosis)

Olfactory function in systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). A longitudinal study and review of the literature. Both SLE and SSc patients with longstanding disease had significant reduction in all stages of the Sniffin' Sticks test (TDI) that maintained stable over a 2–year period. PubMed, Autoimmun Rev, 02/11/2018. (Also see Lupus in Overlap and Brain Involvement)

Long–term follow–up of a combined rituximab and cyclophosphamide regimen in renal anti–neutrophil cytoplasm antibody–associated vasculitis (AAV). This regimen is potentially superior to current standards of care, and controlled studies are warranted to establish the utility of combination drug approaches in the treatment of AAV. PubMed, Nephrol Dial Transplant, 2019 Jan 1;34(1):63-73. (Also see Vasculitis)

Identification of a novel autoantibody against self–vimentin specific in secondary Sjögren's syndrome (sSS). This novel autoantibody is highly specific in the diagnosis of sSS, and the underlying molecular mechanism of the disease might be epitope spreading involved with vimentin. PubMed, Arthritis Res Ther, 2018 Feb 12;20(1):30. (Also see Diagnosis of Sjögren's Syndrome)

Go to Autoimmune News: February 2018

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