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2021 - 2020 - 2019 - 2018

October 2019 Autoimmune News

Evidence for a role of autoinflammation in early-phase psoriasis. IL-1β overexpression in combination with low expression of cytokines that are predominant in late-phase plaque psoriasis may support the role of autoinflammation in early-phase disease. PubMed, Clin Exp Immunol, 09/11/2019. (Also see Psoriasis and Psoriatic Arthritis)

Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis. Exogenous replacement of IL-36 antagonists may be a novel promising therapeutic target for PsA patients. PubMed, Rheumatology (Oxford), 09/03/2019. (Also see Psoriasis and Psoriatic Arthritis)

Dysregulated Fc gamma receptor IIa-induced cytokine production in dendritic cells (DCs) of lupus nephritis patients. We identified that DCs of lupus nephritis patients show increased Fcγ R-induced IL-1β production, which is another important cytokine that promotes kidney inflammation. PubMed, Clin Exp Immunol, 09/11/2019. (Also see Symptoms and Complications of Lupus)

A comparison of three classification criteria sets for Systemic Lupus Erythematosus (SLE) - a study looking at links to outcome and mortality. These findings were clearer in patients negative for non-diagnostic-SLE autoantibodies, who may benefit more from the predictive capacity of the EULAR/ACR set. PubMed, Arthritis Care Res (Hoboken), 09/10/2019. (Also see Systemic Lupus Erythematosus)

The association between lymphopenia and serious infection (SI) risk in rheumatoid arthritis (RA). Lymphocyte counts below 1.0 109 cells/l were associated with higher SI risk in RA patients and may be used as a measure to stratify patients at risk of SI. PubMed, Rheumatology (Oxford), 08/27/2019. (Also see Symptoms and Complications of Rheumatoid Arthritis)

Musculoskeletal ultrasound can improve referrals from dermatology to rheumatology for patients with psoriasis. Due to the high frequency of non-specific pain in psoriasis, it is not possible for every psoriasis patient with joint pain to be assessed by a rheumatologist. PubMed, Br J Dermatol, 09/10/2019. (Also see Psoriasis and Psoriatic Arthritis)

Emerging therapies in rheumatoid arthritis (RA): focus on monoclonal antibodies. Advances in the treatment of RA are attributed to several aspects such as new classification criteria as well as better understanding of the pathogenesis of RA. PubMed, F1000Res, 2019 Aug 30;8. (Also see Treatments for Rheumatoid Arthritis)

Clinical Insights into Diffuse Alveolar Hemorrhage (DAH) in Antiphospholipid Syndrome (APS). DAH is a rare but devastating manifestation of APS patients with or without other systemic autoimmune diseases. PubMed, Curr Rheumatol Rep, 2019 Sep 6;21(10):56. (Also see Antiphospholipid Syndrome)

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial. Our results suggest the concept that IL-1 inhibition may be considered a targeted treatment for RA and T2D. PubMed, PLoS Med, 2019 Sep 12;16(9):e1002901. (Also see Treatments for Rheumatoid Arthritis and Treatments for Diabetes)

Reduction of skin innervation is associated with a severe fibromyalgia (FMS) phenotype. The extent of small fiber pathology is related to symptom severity in FMS and may have implications for the diagnostic classification and treatment of patients with FMS. PubMed, Ann Neurol, 2019 Oct;86(4):504-516. (Also see Fibromyalgia)

Go to Autoimmune News: September 2019

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