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March 2015 Scleroderma News

Overlap Syndrome Distinct in Scleroderma (SSc). This study demonstrates that patients with SSc overlap, on average, carry a higher disease burden than patients with the Limited form. Medpage Today, 03/10/2015. (Also see Scleroderma in Overlap)

A comparison of the predictive accuracy of three screening models for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Ultimately, the choice of SSc-PAH screening algorithm will also depend on cost and ease of application. PubMed, Arthritis Res Ther, 2015 Jan 18;17(1):7. (Also see Pulmonary Hypertension Diagnosis)

Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma. Increased age at scleroderma onset is strongly associated with cancer risk overall. PubMed, Arthritis Rheumatol, 01/20/2015. (Also see Cancer and Scleroderma and Antibodies)

Surgical treatment of systemic sclerosis: Is it justified to offer peripheral sympathectomy earlier in the disease process? Peripheral sympathectomy is a well-tolerated procedure in patients with SSc and is associated with predictable pain relief and ulcer healing in the majority of patients. PubMed, Microsurgery, 01/14/2015. (Also see Digital Sympathectomy)

Lung structure and function relation in systemic sclerosis (SSc): Application of lung densitometry Perc85 is an optimal lung density parameter confirming a lung parenchymal structure-function relation in SSc. European Journal of Radiology, 01/22/2015. (Also see Diagnosis of Scleroderma Pulmonary Involvement)

Multimodality Thoracic Imaging of Juvenile Systemic Sclerosis: Emphasis on Clinical Correlation and High-Resolution CT of Pulmonary Fibrosis. Common thoracic findings in juvenile systemic sclerosis and treatment decisions and prognostic assessment are directly related to imaging findings along with clinical evaluation. PubMed, AJR Am J Roentgenol, 2015 Feb;204(2):408-22. (Also see Juvenile Scleroderma and Diagnosis of Scleroderma Pulmonary Involvement)

Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population. An estimated systolic pulmonary artery pressure >36 mmHg at baseline echocardiography was significantly and independently associated with reduced survival. PubMed, Rheumatology (Oxford), 01/17/2015. (Also see Diagnosis of Scleroderma Heart Involvement)

Cardiac biomarkers in systemic sclerosis: contribution of high-sensitivity cardiac troponin in addition to N-terminal pro-brain natriuretic peptide. The easily obtained biomarkers may be useful for systematic evaluation and stratification of SSc patients, especially to identify those at risk of pulmonary hypertension. PubMed, Arthritis Care Res (Hoboken), 01/20/2015. (Also see Scleroderma Cardiac Involvement and Scleroderma Biomarkers)

Emerging roles of innate immune signaling and toll-like receptors (TLRs) in fibrosis and systemic sclerosis (SSc). Recent advances and emerging paradigms are highlighted for understanding the regulation, complex functional roles, and therapeutic potential of TLRs in SSc pathogenesis. PubMed, Curr Rheumatol Rep, 2015 Jan;17(1):474. (Also see Skin Fibrosis)

Decrease of LL-37 in systemic sclerosis (SSc): a new marker for interstitial lung disease (ILD)? The circulating levels of LL-37 in SSc patients were investigated as lower LL-37 levels may be associated with the development of ILD. PubMed, Clin Rheumatol, 01/20/2015. (Also see Pulmonary Fibrosis Biomarkers and Scleroderma Biomarkers)

Intact Calibers of Retinal Vessels in Patients with Systemic Sclerosis (SSc). The evidence that retinal microcirculation is spared in SSc suggests that fibroproliferative vasculopathy may depend on specific cellular or soluble factors not present in the retinal environment. PubMed, J Rheumatol, 02/01/2015. (Also see Retinopathy and Systemic Sclerosis)

Go to Scleroderma Medical News: February 2015

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