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May 2015 Scleroderma News

Lower Limb Strength Impacts Systemic Sclerosis Patient's Quality of Life and Functional Capacity, According to Study Patients with systemic sclerosis have reduced respiratory muscle and quadriceps strength and these muscles are more susceptible to fatigue. Scleroderma News, 03/30/2015. (Also see Musculoskeletal Involvement)

Effectiveness of non-pharmacological interventions in systemic sclerosis: A systematic review. An international consensus should be established to prioritize primary targets for non-pharmacological treatment, the content of interventions, and to agree on a core set of outcome measures. PubMed, Arthritis Care Res (Hoboken), 04/01/2015. (Also see Alternative Therapies)

Adherence to recommendations for cervical and breast cancer screening in systemic sclerosis. A very high percentage of SSc female patients adhered to programs for the early detection of cervical and breast cancer. PubMed, Reumatismo, 2015 Mar 31;66(4):264-9. (Also see Cancer and Scleroderma)

Epitope specificity determines pathogenicity and detectability of anti-PDGFRa autoantibodies in systemic sclerosis. Agonistic anti-PDGFRa autoantibodies are enriched in SSc sera and recognize specific conformational epitopes, that can be used to discriminate agonistic from nonagonistic antibodies and block PDGFRa signaling in SSc. PubMed, Arthritis Rheumatol, 03/25/2015. (Also see Autoantibodies)

The relationship between nailfold capillaroscopic assessment and telangiectasia score with severity of peripheral vascular involvement in systemic sclerosis. Digital ulcer history and severe PVI in SSc were associated with capillary loss and microangiopathy. PubMed, Clinical and Experimental Rheumatology, 03/23/2015. (Also see Nailfold Videocapillaroscopy, Vascular Involvement and Telangiectasia)

Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma (SSc). In Japanese patients, anti-PM/Scl antibodies are only very rarely found, and they are not always specific for dermatomyositis (DM) or SSc. Arthritis Research and Therapy, 03/11/2015. (Also see Antibodies in Systemic Scleroderma)

Factors influencing the occupational trajectory of patients with systemic sclerosis (SSc): a qualitative study. The decisions patients with SSc take concerning work depend on an interplay between many factors and, especially, on the patients' personal interpretation of these factors. PubMed, Clin Exp Rheumatol, 03/20/2015. (Also see Living with a Chronic Illness)

Update on juvenile systemic sclerosis. Currently, treatment approaches are based only on adult data, and problems exist in extrapolating these data to a pediatric population. PubMed, Curr Rheumatol Rep, 2015 Mar;17(3):491. (Also see Juvenile Scleroderma)

Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis (SSc). An immuno-inflammatory environment and aberrant vascular repair are intimately linked to fibroblast activation in lesional skin in SSc. Arthritis Research and Therapy, 03/23/2015. (Also see Causes of Scleroderma: Fibroblasts)

Just How Common Is Hydroxychloroquine (HCQ) Retinopathy? There remains considerable debate about the safety of HCQ and the exact prevalence of retinopathy resulting from its use. Medscape, 04/07/2015. (Also see DMARD's)

Go to Scleroderma Medical News: April 2015

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