Scleroderma renal crisis (SRC) or thrombotic thrombocytopenic purpura (TTP): seeing through the masquerade. SRC can easily be mistaken for TTP in clinical practice as SRC masquerades as TTP until the clinical picture changes and certain laboratory test and kidney biopsy results confirm otherwise. PubMed, Lab Med, 2015 Spring;46(2):e39-44. (Also see Scleroderma Kidney (Renal) Involvement)
Difficulties in diagnosis of systemic sclerosis-related interstitial lung disease (SSc-ILD). The diagnosis of SSc-ILD could maybe be made sooner if a capillaroscopy was performed earlier, according to the current criteria of early SSc. PMC, Respirol Case Rep, 2015 Sep; 3(3): 99–101. (Also see Pulmonary Fibrosis Diagnosis and Nailfold Capillaroscopy)
Systemic Sclerosis Patients Have Reduced Incidence of Crohn’s Disease, According to Study. The findings led the team to conclude that systemic sclerosis is associated with a reduced incidence of Crohn’s disease, regardless of the patient’s age and sex. Scleroderma News, 09/24/2015. (Also see Inflammatory Bowel Disease)
Systemic Sclerosis Patients Found to Have Low Vitamin D Levels, Reduced Bone Mineral Density & Total Mineral Content. Findings suggest that skin thickness in SSc patients could be one factor in determining low circulating levels of vitamin D that in turn could play a significant role in the reduction of bone mineral density and total mineral content. Scleroderma News, 09/23/2015. (Also see Vitamin D)
High False Negative Rate in Detecting Scleroderma (SSc) Lung Disease Associated With Pulmonary Function Tests. These findings indicate that high–resolution computed tomography scans, even when conducted by the most skilled radiologists, may lead to false negatives in detecting SSc of the lung. Scleroderma News, 09/21/2015. (Also see Pulmonary Fibrosis Diagnosis)
Increased risk of papillary thyroid cancer (TC) in systemic sclerosis associated with autoimmune thyroiditis. Patients with SSc have an increased risk of malignancy compared with the general population and these data suggest a high prevalence of papillary TC, in particular in the presence of thyroid autoimmunity. PubMed, Rheumatology (Oxford), 09/30/2015. (Also see Autoimmune Thyroid Diseases and Cancer and Scleroderma)
Calcinosis: pathophysiology and management. This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). PubMed, Curr Opin Rheumatol, 2015 Nov;27(6):542–8. (Also see Calcinosis)
Cancer and scleroderma (SSc): a paraneoplastic disease with implications for malignancy screening. Aggressive malignancy screening in SSc patients may aid in early cancer detection and further study is required to determine whether cancer therapy could improve scleroderma outcomes in this patient population. PubMed, Curr Opin Rheumatol, 2015 Nov;27(6):563–70. (Also see Cancer and Scleroderma)
Influence of tyrosine kinase 2 (TYK2) in systemic sclerosis (SSc) susceptibility: a new locus in the IL-12 pathway. The association of TYK2 with SSc and reinforcing the relevance of the IL-12 pathway in SSc pathophysiology is reported for the first time. PubMed, Ann Rheum Dis, 09/02/2015. (Also see Causes of Scleroderma: Interleukins)
The Canadian Systemic Sclerosis (SSc) Oral Health Study V: Relationship Between Disease Characteristics and Oral Radiologic Findings in Systemic Sclerosis. In SSc, a wide periodontal ligament may reflect generalized overproduction of collagen and mandibular erosions are related to local factors in the oral cavity. PubMed, Arthritis Care Res (Hoboken), 09/28/2015. (Also see Temporo-Mandibular Joint and Systemic Sclerosis)
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