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February 2017 Scleroderma News

Imaging of Heart Disease in Women. For the diagnosis and management of ischemic heart disease, it is important for radiologists to be familiar with the unique considerations for imaging women with heart disease. PubMed, Radiology, 2017 Jan;282(1):34-53. (Also see Heart (Cardiac) Symptoms)

Morphoea with prominent plasma cell endoneuritis. We report two cases of morphoea that histologically showed plasma cell endoneuritis associated with subtle dermal sclerosis. PubMed, Clin Exp Dermatol, 01/04/2017. (Also see Morphea)

Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis–related interstitial lung disease. Findings suggest that intermediate–term changes in CXCL4 may have predictive significance for long–term progression of SSc–ILD in patients receiving immunosuppressive therapy. PubMed, Arthritis Res Ther, 2016 Dec 30;18(1):305. (Also see Treatments for Pulmonary Fibrosis and Immunosuppressants)

Case Report: Delayed onset of posterior reversible encephalopathy syndrome in a case of scleroderma renal crisis (SRC) with maintenance hemodialysis. This case demonstrates that microangiopathy and extra–renal manifestations can develop even in SRC patients with end–stage renal disease and that these manifestations can be successfully managed. PubMed, Medicine (Baltimore). (Also see Kidney (Renal) Involvement)

Reduced perfusion in systemic sclerosis digital ulcers (DUs) (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate (GTN). DUs (both fingertip and extensor) were responsive to topical GTN, with an increase in perfusion to the ischaemic DU centre. PubMed, Microvasc Res, 2016 Dec 24;111:32-36. (Also see Treatments for Digital Ulcers: Topical)

Case Report: Acro–osteolysis and calcinosis in patient with scleroderma. We present a unique case of progressive acro–osteolysis of the distal phalanges and articular calcifications in a patient with scleroderma. PubMed, Acta Orthop Traumatol Turc. (Also see Bone Resorption and Calcinosis)

Clinical correlates of faecal incontinence (FI) in systemic sclerosis (SSc): identifying therapeutic avenues. Other than targeting anorectal dysfunction, concomitant treatment of clinical correlates could lead to improvement in FI and quality of life in SSc. PubMed, Rheumatology (Oxford), 12/24/2016. (Also see Bowel Dysfunction)

Improved cough and cough–specific quality of life in patients treated for scleroderma–related interstitial lung disease (SSc–ILD): Results of Scleroderma Lung Study II. Frequent cough occurs commonly in SSc–ILD and might serve as a useful surrogate marker of treatment response in SSc–ILD trials. PubMed, Chest, 12/22/2016. (Also see Clinical Trials)

Scleroderma (SSc) peripheral B lymphocytes secrete interleukin-6 and TGF–ß and activate fibroblasts. Peripheral B lymphocytes from SSc patients secreted IL-6 and TGF–ß, and activated fibroblasts in vitro. PubMed, Arthritis Rheumatol, 12/19/2016. (Also see Fibroblasts and Interleukins)

The role of local temperature and other clinical characteristics of localized scleroderma (LS) as markers of disease activity. There is a possible role for temperature and other clinical characteristics as predictors of activity of LS and more studies and better definitions of activity are needed. PubMed, Int J Dermatol, 2017 Jan;56(1):63-67. (Also see Localized Scleroderma)

Go to Scleroderma Medical News: January 2017

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