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March 2017 Scleroderma News

Early mortality in a multinational systemic sclerosis (SSc) inception cohort. Early mortality in SSc is substantial and prevalent cohorts underestimate mortality in SSc by failing to capture early deaths, particularly in men and those with diffuse disease. PubMed, Arthritis Rheumatol, 12/28/2016. (Also see Prognosis and Mortality)

Systemic sclerosis (SSc) and exposure to heavy metals: A case control study of 100 patients and 300 controls. Occupational exposure should be systematically checked in all SSc patients at diagnosis and the association between SSc and occupational exposure may be variable according to patients' gender. PubMed, Autoimmun Rev, 2017 Mar;16(3):223-230. Also see Causes of Scleroderma: Solvents and Mercury Exposure)

"It's not me, it's not really me." Insights from patients on living with systemic sclerosis: An interview study. Access to psychosocial care to support the patients' role and functioning capacity, as well as communication and education may potentially improve treatment satisfaction, self–efficacy, adherence and outcomes in patients with systemic sclerosis. PubMed, Arthritis Care Res (Hoboken), 01/27/2017. (Also see Coping with Scleroderma)

Kidney transplantation in patients with systemic sclerosis (SSc): a nationwide multicenter study. In our study, patient and graft survivals after kidney transplantation can be considered as excellent and in the absence of extra–renal contraindication, SSc patients presenting with end–stage renal disease should be considered for kidney transplantation. PubMed, Transpl Int, 01/25/2017. (Also see Kidney Transplant)

Comparison of Self–Efficacy for Managing Chronic Disease between patients with systemic sclerosis (SSc) and other chronic conditions: a systematic review. Compared to patients with other diseases not enrolled in programs to improve self–efficacy, SSc patients report lower self–efficacy scores than most patient groups. PubMed, Rheumatol Int, 2017 Feb;37(2):281-292. (Also see Coping with Scleroderma)

Systemic sclerosis (SSc) with anti-RNA polymerase III positivity following silicone breast implant rupture: possible role of B–cell depletion and implant removal in the treatment. This result may support data suggesting that B-cell depleting therapy may decrease specific autoantibody level in SSc patients, and that these changes are associated with disease improvement. PubMed, Rheumatol Int, 02/03/2017. (Also see B Cells and T Cells and Artificial Joints and Silicone Breast Implants)

Innate Immunity in Systemic Sclerosis (SSc). Currently, no effective therapy exists and exploiting the innate immune system perturbation may be one possible avenue. Innate immune dysregulation is key in SSc pathogenesis and may represent a novel target. PubMed, Curr Rheumatol Rep, 2017 Jan;19(1):2. (Also see Fibroblasts)

TIM-1 defines a human regulatory B cell (Bregs) population that is altered in frequency and function in systemic sclerosis (SSc) patients. TIM-1 is a unique marker for the identification of a human IL-10+ Breg subpopulation which is partially superimposed with transitional B cells. Alterations in TIM-1+ B cells could contribute to the development of autoimmune diseases such as SSc. PubMed, Arthritis Res Ther, 2017 Jan 19;19(1):8. (Also see B Cells and T Cells)

Cardiac involvement (CI) in systemic sclerosis (SSc) : differences between clinical subsets and influence on survival. CI increased the mortality and appeared at a higher rate, especially during the first year after SSc onset and screening for heart involvement should be performed at diagnosis and during follow-up. PubMed, Rheumatol Int, 2017 Jan;37(1):75-84. (Also see Cardiac (Heart) Involvement)

Esophageal Motor Abnormalities in Patients With Scleroderma (SSc) : Heterogeneity, Risk Factors, and Effects on Quality of Life. Although severe dysmotility is more common in patients with SSc than in controls, we observed the so–called scleroderma esophagus in only one–third of patients with SSc. PubMed, Clin Gastroenterol Hepatol, 2017 Feb;15(2):207-213.e1. (Also see Esophageal (Throat) Involvement)

Go to Scleroderma Medical News: February 2017

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