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September 2017 Scleroderma News

Risk factors and outcome of Thai patients with scleroderma (SSc) renal crisis (SRC): a disease duration-matched case control study. SRC was an uncommon complication in Thai patients with SSc, but is associated with high mortality. PubMed, Int J Rheum Dis, 07/27/2017. (Also see Kidney (Renal) Involvement)

Downregulation of Aquaporin3 in Systemic Sclerosis (SSc) Dermal Fibroblasts. SSc manifestations like skin dryness, abnormal wound healing, and fibrotic lesions may be related to downregulation of AQP3 in SSc fibroblasts. PubMed, Iran J Allergy Asthma Immunol, 2017 Jun;16(3):228-234. (Also see Fibroblasts)

Severity and features of frailty in systemic sclerosis–associated interstitial lung disease (Ssc-ILD). This study showed that frailty is highly prevalent in SSc–ILD patients and may help identify those less likely to tolerate potentially toxic pharmaceutical therapies or lung transplant. PubMed, Respir Med, 2017 Aug;129:1-7. (Also see Symptoms and Complications of Pulmonary Fibrosis)

Preclinical Study Shows IVA337’s Potential in Treating SSc Skin and Cardiovascular Complications. Inventiva’s lead therapy candidate IVA337 for the treatment of systemic sclerosis (SSc) was shown to prevent the progression of lung fibrosis and the remodeling of blood vessels in preclinical animal models of lung fibrosis and systemic sclerosis. Scleroderma News, 07/28/2017. (Also see Clinical Trials)

Changes in pulmonary exercise haemodynamics in scleroderma (SSc): a 4–year prospective study. Patients with SSc developed mild deterioration of pulmonary exercise hemodynamics and exercise capacity over a 4–year follow–up period, indicating mild but significant progression of pulmonary vascular disease. PubMed, Eur Respir J, 2017 Jul 13;50(1). (Also see Pulmonary Hypertension)

Mechanics and prognostic value of left (LV) and right ventricular (RV) dysfunction in patients with systemic sclerosis. RV dysfunction was associated with adverse outcome, independent of and incremental to clinical and LV deformation parameters in SSc. European Heart Journal, 08/11/2017. (Also see Cardiac (Heart) Involvement)

The roles of dermal white adipose tissue (DWAT) loss in scleroderma skin fibrosis. The loss of skin–protective mechanisms with DWAT loss further contributes to skin fibrosis and injury. PubMed, Curr Opin Rheumatol, 08/10/2017. (Also see Skin Fibrosis)

Disease–related autoantibody (autoABs) profile in patients with systemic sclerosis (SSc). Anti-Topo I, anti-CENP, and anti-RNA pol III are the most prevalent autoAbs in SSc. PubMed, Autoimmunity, 2017 Jul 27:1-8. (Also see Antibodies)

Intestinal microbiome in scleroderma (SSC): recent progress. Therapeutic trials are needed to investigate whether dietary interventions or fecal transplantation can restore the gut microbial balance and improve health outcomes in SSc. PubMed, Curr Opin Rheumatol, 07/15/2017. (Also see Bowel Dysfunction)

Are there risk factors for scleroderma-related calcinosis? Calcinosis was common in both limited and diffuse systemic sclerosis; both longer disease duration and osteoporosis were independently associated with calcinosis. PubMed, Mod Rheumatol, 2017 Jul 19:1-5. (Also see Calcinosis)

Go to Scleroderma Medical News: August 2017

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