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Scleroderma Newsroom
ISN News Manager: Jo Frowde
Media Stories
Scleroderma Archive
We maintain news archives for the most recent 3 years.
2020: Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
2021 - 2020 - 2019 - 2018

March 2020 Scleroderma News

Decreased CCN3 in Systemic Sclerosis endothelial cells contributes to impaired angiogenesis. CCN3 may represent a promising therapeutic target for SSc patients presenting with vascular involvement. PubMed, J Invest Dermatol, 01/16/2020. (Also see Vascular Involvement)

Impaired Swallowing Linked to Depression, Lower Quality of Life in Scleroderma, Study Finds. Swallowing trouble in people with scleroderma is associated with lower quality of life and a higher incidence of depression, a study found. Scleroderma News, 02/05/2020. (Also see Dysphagia and Depression)

Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells (DCs) via retinoic acid-mediated regulatory T cell induction: A role in scleroderma (SSc). This study identified a critical role of dermal DCs as a regulator of Treg development through RALDH1 in bleomycin-treated mice and possibly in human SSc. PubMed, J Dermatol Sci, 01/15/2020. (Also see Dendritic Cells)

Exploring the impact of paediatric localized scleroderma (LS) on health-related quality of life (HRQoL): Focus groups with youth and caregivers. This is the first qualitative study of HRQoL in LS to include all major LS subtypes. PubMed, Br J Dermatol, 01/18/2020. (Also see Coping with a Child's Chronic Illness)

Digital ulcers (DUs) in systemic sclerosis: their epidemiology, clinical characteristics, and associated clinical and economic burden. DUs place a large burden on the patient and healthcare system through reduced health-related quality of life and increased healthcare resource utilization and associated cost. PubMed, Arthritis Res Ther, 2019 Dec 23;21(1):299. (Also see Digital Ulcers)

The Glittre Activities of Daily Living Test in women with scleroderma and its relation to hand function and physical capacity. The Glittre Activities of Daily Living Test may be used in clinical practice to evaluate the performance of activities of daily living by people with scleroderma. PubMed, Clin Biomech (Bristol, Avon), 2020 Jan 11;73:71-77. (Also see Hand and Joint Involvement)

Whole blood gene expression profiling distinguishes systemic sclerosis (SSc)-overlap syndromes from other subsets. Besides the two major subsets, limited and diffuse SSc, a substantial number of SSc cases exhibit overlap features of another rheumatic disease. PubMed, J Eur Acad Dermatol Venereol, 01/15/2020. (Also see Scleroderma in Overlap)

Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis (SSc). Analysis indicated that there were common pathological clusters that contributed to the pathogenesis of SSc in different tissues. PubMed, BMC Med Genomics, 2019 Dec 27;12(1):199. (Also see Cluster Studies)

Pulmonary veno-occlusive disease (PVOD): a probably underdiagnosed cause of pulmonary hypertension in systemic sclerosis. Patients with PVOD usually have a poor prognosis and might experience acute pulmonary oedema after introduction of pulmonary vasodilators. PubMed, Clin Rheumatol, 01/22/2020. (Also see Pulmonary Hypertension Symptoms and Complications)

Electrocardiographic markers for the prediction of ventricular arrhythmias in patients with systemic sclerosis. The question is whether certain ECG parameters reflecting ventricular repolarization may help to recognize scleroderma patients with increased risk for ventricular arrhythmias and sudden cardiac death. PubMed, Rheumatology (Oxford), 01/14/2020. (Also see Complications with Heart Involvement)

Go to Scleroderma Medical News: February 2020

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