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Scleroderma Newsroom
ISN News Manager: Jo Frowde
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Scleroderma Archive
We maintain news archives for the most recent 3 years.
2020: Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
2021 - 2020 - 2019 - 2018

August 2020 Scleroderma News

Long-Term Efficacy of Methotrexate Demonstrated in Pediatric Linear Scleroderma. Patients treated with methotrexate (MTX) for pediatric linear scleroderma may achieve complete and long-lasting remission. Rheumatology Advisor, 06/22/2020. (Also see Juvenile Scleroderma and Juvenile Scleroderma Research)

Pregnancy in Systemic Sclerosis (SSc): Results of a Systematic Review and Meta-analysis. Pregnancies involving SSc have increased frequency of miscarriages,intrauterine growth retardation, preterm deliveries, and newborns with low birth weight compared to healthy controls. PubMed, J Rheumatol, 2020 Jun 1;47(6):881-887. (Also see Pregnancy)

Systemic Sclerosis (SSc) Is an Independent Risk Factor for Ischemic Heart Disease (IHD), Especially in Patients Carrying Certain Antiphospholipid Antibodies. Patients with SSc are at higher risk for developing IHD with an additional risk for the latter in those positive for anti-cardiolipin or anti-beta2GPI. PubMed, Eur J Intern Med, 06/30/2020. (Also see Cardiac (Heart) Involvement and Antiphospholipid Syndrome)

Bioactive Plasma Mitochondrial DNA (mtDNA) Is Associated With Disease Progression in Scleroderma Associated Interstitial Lung Disease (SSc-ILD). These findings demonstrate an unrecognized connection between extracellular vesicles-encapsulated mtDNA, clinical outcomes, and intracellular DNA-sensing pattern recognition receptors activation in SSc-ILD. PubMed, Arthritis Rheumatol, 06/30/2020. (Also see Pulmonary Fibrosis)

Cardiovascular Risk Factors and Atherosclerotic Cardiovascular (CV) Events Among Incident Cases of Systemic Sclerosis (SSc). Patients with SSc are at ⦥2-fold increased risk for experiencing a CV event compared with persons without SSc. PubMed, Mayo Clin Proc, 2020 Jul;95(7):1369-1378. (Also see Vascular Involvement)

Serious Infections in People With Systemic Sclerosis: A National US Study. Outcomes in people with SSc hospitalized with serious infections have improved over time. PubMed, Arthritis Res Ther, 2020 Jun 29;22(1):163. (Also see Infection)

Neutrophil Extracellular Traps (NET) Generation Relates With Early Stage and Vascular Complications in Systemic Sclerosis (SSc). Neutrophils and especially NETosis represent new physiopathological and therapeutic fields in SSc. PubMed, J Clin Med, 2020 Jul 7;9(7):E2136. (Also see Vascular Involvement)

Avascular Necrosis (AVN) in Systemic Sclerosis (SSc) Patients: A Case-Based Review of Demographics, Presentation, and Management. A case of multifocal AVN in an SSc patient and a review of literature on the previously reported cases of SSc-related AVN. PubMed, Clin Rheumatol, 07/09/2020. (Also see Musculoskeletal Involvement)

Case Report: Multifactorial Pulmonary Hypertension in Systemic Sclerosis. We present a case of pulmonary arterial hypertension (PAH) in a patient with rapidly progressing symptoms to highlight the need for an early and thorough diagnostic workup. PubMed, Cureus. (Also see Pulmonary Hypertension Diagnosis)

An update on the pharmacotherapeutic options and treatment strategies for systemic sclerosis. Combining therapies to address the individual manifestations of SSc is a cornerstone to the comprehensive management of this condition. PubMed, Expert Opin Pharmacother, 2020 Jul 17;1-15. (Also see Treatments - General)

Go to Scleroderma Medical News: July 2020

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