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2020 - 2019 - 2018 - 2017

July 2020 Scleroderma News

Treatment With Mycophenolate (MMF) and Cyclophosphamide (CYC) Leads to Clinically Meaningful Improvements in Patient-Reported Outcomes in Scleroderma Lung Disease (SSc-ILD). Treatment with CYC and MMF improved overall health-related quality of life in patients with SSc-ILD. PubMed, ACR Open Rheumatol, 05/20/2020. (Also see Cellcept and Cyclophosphamide)

TLY012 Receives FDA Orphan Drug Status for Systemic Scleroderma. An early study showed that TLY012 killed skin myofibroblasts from people with scleroderma, while it did not have the same effect in cells derived from people without the disease. Scleroderma News, 05/31/2020. (Also see Fibroblasts)

COVID-19 Delaying Rare Disease and Gene Therapy Trials, Pharma Execs Say. The ongoing COVID-19 pandemic has begun to cause delays in the development of gene therapies to treat a variety of rare diseases. Scleroderma News, 05/28/2020. (Also see Clinical Trials)

Recommendations for Diagnosing and Managing Systemic Sclerosis. Understanding the totality of systemic sclerosis is key to successful diagnosis and management of this rare disease. Rheumatology Advisor, 06/01/2020. (Also see Diagnosis of Scleroderma)

Effects of Polyurethane Foam Dressings as an Add-on Therapy in the Management of Digital Ulcers (DUs) in Scleroderma Patients. The combined management of DUs can improve both the onset of new DUs and DU's healing thus leading to a better outcome. PubMed, Transl Med UniSa, 2020 May 31;22:10-14. (Also see Topical Treatments)

Renal Involvement in Systemic Sclerosis: An Update. There is a strong association between renal involvement and patients' outcomes in systemic sclerosis. PubMed, Kidney Blood Press Res, 2020 Jun 10;1-17. (Also see Kidney (Renal) Involvement)

The Systemic Sclerosis Patient in the COVID-19 Era: The Challenging Crossroad Between Immunosuppression, Differential Diagnosis and Long-Term Psychological Distress. The rheumatologist in daily clinical practice should carefully differentiate the possible COVID-19 infection in order to optimize the patient management. PubMed, Clin Rheumatol, 2020 Jun 8;1-5. (Also see Correlation between Pulmonary Fibrosis and other Diseases or Complications)

Interleukin-32 in Systemic Sclerosis (SS), a Potential New Biomarker for Pulmonary Arterial Hypertension (PAH). Our study suggested that sera determination of IL-32 may be a promising approach to evaluate the presence of PAH in SSc patients. PubMed, Arthritis Res Ther, 2020 Jun 1;22(1):127. (Also see Interleukins and Pulmonary Hypertension Diagnosis)

Ultrasound (US) Detection of Calcinosis and Association With Ulnar Artery Occlusion in Patients With Systemic Sclerosis (SSc). US was sensitive and highly specific in detecting calcinosis in SSc. PubMed, Arthritis Care Res (Hoboken), 05/31/2020. (Also see Calcinosis)

Development and Assessment of a Novel Lung Ultrasound (LUS) Interpretation Criteria for the Detection of Interstitial Lung Disease in Systemic Sclerosis (SSC-ILD). We developed a novel LUS examination technique and interpretation criteria that are highly sensitive and specific for SSc-ILD detection in an SSc cohort. PubMed, Arthritis Care Res (Hoboken), 05/31/2020. (Also see Pulmonary Fibrosis Diagnosis)

Go to Scleroderma Medical News: June 2020
 

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