New Computer–based Analysis Method Identifies Scleroderma Patients Who May Benefit Most from Stem Cell Transplant. The analysis of gene profile in blood samples may help identify scleroderma patients who could benefit most from stem cell transplant, a research study suggests. Scleroderma News, 11/01/2018. (Also see Stem Cell (Bone Marrow) Transplantation)
Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis (SSc) Patients At Risk for Pulmonary Hypertension (PH), in the PHAROS Registry. Risk factors for poor outcome in patients with SSc who are at risk for PH were similar to others with SSc–PH and SSc–pulmonary arterial hypertension. PubMed, J Rheumatol, 10/01/2018. (Also see Pulmonary Hypertension Prognosis)
Comorbidity of localized scleroderma and primary biliary cholangitis (PBC). The coexistence of morphea, anti–mitochondrial antibodies positivity and PBC is a rare but possible association. PubMed, J Dtsch Dermatol Ges, 2018 Nov;16(11):1323-1327. (Also see Conditions Associated with Morphea and Liver Involvement)
Ubiquitination in Scleroderma (SSc) Fibrosis and Its Treatment. In this review, we will summarize the molecular mechanisms of ubiquitination in patients with SSc and explore the potential targets for treatment. PubMed, Front Immunol, 2018 Oct 17;9:2383. (Also see Skin Fibrosis)
Long–term effects of immunosuppressive therapy on lung function in scleroderma patients. Cyclophosphamide does not appear to result in clinically significant improvement of pulmonary function but fulfilled criteria of stable disease. PubMed, Clin Rheumatol, 2018 Nov;37(11):3043-3050. (Also see Immunosuppressants and Treatments for Pulmonary Fibrosis)
Skin Cancer and Other Skin Complications for People with Scleroderma. The skin is the largest organ in the body and is affected in most scleroderma patients. Scleroderma News, 11/07/2018. (Also see Cancer and Scleroderma)
Joint Contractures, Ulcerations, Severe Raynaud’s Linked to Impaired Hand Function in Scleroderma. The presence of moderate or severe small joint contractures, finger ulcerations, and the severity of Raynaud’s phenomenon show the strongest association with impaired hand function in scleroderma patients, a study reports. Scleroderma News, 11/06/2018. (Also see Raynaud’s and Hand and Joint Involvement)
Impact of EUSTAR standardized training on accuracy of modified Rodnan skin score (mRSS) in patients with systemic sclerosis. New EUSTAR standardized mRSS training significantly enhanced mRSS accuracy, especially in participant with less previous experience in skin scoring. PubMed, Int J Rheum Dis, 11/05/2018. (Also see Skin Fibrosis)
CCN proteins as potential actionable targets in scleroderma (SSc). We discuss the possible implication of CCN proteins in SSc pathogenesis, with a special focus on skin features, and identify the potential actionable CCN targets. PubMed, Exp Dermatol, 10/17/2018. (Also see Causes of Scleroderma and Skin Fibrosis)
Case Report: Parry-Romberg syndrome (PRS) in a patient with scleroderma. A clinical diagnosis of PRS was made due to be followed up by dermatology, rheumatology and maxillofacial surgery with the aim of reconstructive surgery once symptoms stabilise. BMJ Case Reports. (Also see Parry Rombergs Syndrome)
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