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Behçet's Disease

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Symptoms
Case Reports
Causes
Diagnosis
Treatments

Overview: What is Behçet's?

Behcets KaleidoscopeBehçet's is quite likely an autoimmune disease, and a type of vasculitis. It is not contagious. It can cause mouth and genital sores, eye inflammation, arthritis, and even heart problems. It is not curable. It is usually treated with immunosuppressant medications. (Also see Autoimmune Diseases and Vascular Involvement)

Symptoms and Complications

Clinical manifestations of Behçet’s disease (BD) depending on sex and age: results from Japanese nationwide registration. We showed that clinical phenotype in early phase of BD was different depending on onset age and sex. Rheumatology, 08/08/2017.

Clinical analysis of Behçet's disease(BD) associated with pulmonary vascular disease (PVD). PVD is a rare complication of BD and management of immunosuppressive agents may improve the prognosis and should be recommended. PubMed, Zhonghua Jie He He Hu Xi Za Zhi, 2017 May 12;40(5):343-348.

Fibromyalgia in Behçet's disease: a narrative review. PVD is a rare complication of BD and management of immunosuppressive agents may improve the prognosis and should be recommended. PubMed, Br J Pain, 2017 May;11(2):97-101. (Also see Fibromyalgia)

Procoagulant microparticles are increased in patients with Behçet's disease (BD) but do not define a specific subset of clinical manifestations. Although inactive BD patients had high values of procoagulant MP, they did not differentiate between BD patients with or without thrombosis. PubMed, Clin Rheumatol, 02/26/2015.

Most Common Symptoms and Signs of Behçet's Disease. Behçet's disease is not contagious; it is not spread from one person to another. The four most common symptoms (as listed) are mouth sores, genital sores, inflammation inside of the eye, and skin problems. American Behçet's Disease Association.

Case Reports

(Case Report) A case study of Neuro-psycho-Behçet's Syndrome presenting with psychotic attack. To our knowledge, this is the first case report of Neuro-Behçet's Syndrome that presents with an acute psychotic attack. Clinical Neurology and Neurosurgery.

(Case Report) Neuro-Behçet's disease presenting with amnesia and frontal dysfunction. We report a 48-year-old patient with neuro-Behçet's disease who presented with the combination of severe memory impairment and frontal/executive dysfunction. Clinical Neurology and Neurosurgery.

(Case Report) Behçet's disease (BD) associated with celiac disease (CD): a very rare association. There are common findings between Behçet's disease (BD) and celiac disease (CD); however, association in the same patient is a rarity. We relate the third case in the literature of this overlap in a 40-year-old woman with history of obstipation since her childhood. Ascertaining whether pathogenic mechanisms are common in these two conditions requires further investigation. Rheumatology International. (Also see Celiac Disease)

Causes

Behçet's Disease: Causes. Doctor's don't know what causes Behçet's disease. Many believe Behçet's disease is a form of autoimmune disorder. Behçet's disease is likely caused by a combination of genetic and environmental factors. Mayo Clinic.

Associations between vitamin D receptor polymorphisms and susceptibility to Behçet's disease: A meta–analysis. This meta–analysis demonstrated the association between FokI and ApaI polymorphisms in VDR gene with the risk of BD. PubMed, Immunol Invest, 2018 Feb 1:1-14. (Also see Vitamin D Deficiency)

Serum Growth differentiation factor–15 (GDF–15) level in Behçet's disease: relationships between disease activity and clinical parameters. GDF–15 may play a role in the progression and pathway of Behçet's joint involvement and erythema nodosum that is independent of classic inflammatory response measures. PubMed, Int J Dermatol, 05/21/2016.

Diagnosis

Screening and Diagnosis. No tests can determine definitively whether or not you have Behçet's disease. Instead, your doctor relies primarily on your signs and symptoms to diagnose Behçet's disease. Mayo Clinic.

Circulating prolactin levels and Behçet's disease: A meta–analysis. This meta–analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls. PubMed, Cell Mol Biol (Noisy-le-grand), 2018 Jan 31;64(1):14-18.

Treatments

Treatments for Behçet's Disease. There is no cure for Behçet's disease. Treatment typically focuses on reducing discomfort and preventing serious complications. Corticosteroids and other medications that suppress the immune system may be prescribed to treat inflammation. American Behçet's Disease Association.

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