Chronic Fatigue Syndrome (CFS)

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CFS KaleidoscopeChronic Fatigue Syndrome (CFS) is a chronic, incurable illness with many symptoms. It is best known for it's hallmark symptom of longlasting severe fatigue. However it can also cause insomnia, exercise intolerance, widespread joint and muscle pain, memory and concentration problems, tender lymph nodes, sore throat, and headaches. (Also see Autoimmune Diseases)

What is Chronic Fatigue Syndrome? Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Persons with CFS most often function at a substantially lower level of activity than they were capable of before the onset of illness.

Chronic fatigue syndrome and the immune system: Where are we now? In this review, we will discuss the potential of different components of the immune system to be involved in the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome. PubMed, Neurophysiol Clin, 2017 Apr;47(2):131-138.

Causes of CFS

Causes of Chronic Fatigue Syndrome. The World Health Organization (WHO) has classified CFS as a chronic (long-term) neurological condition and this classification has been accepted by the Department of Health. However, the WHO's decision remains controversial and is not accepted by everyone working in the field. NHS.

Diagnosis of CFS

Chronic Fatigue Syndrome. In general, in order to receive a diagnosis of chronic fatigue syndrome, a patient must satisfy two criteria: (1) Have severe chronic fatigue of six months or longer duration with other known medical conditions excluded by clinical diagnosis, and (2) Concurrently have four or more of the following symptoms: substantial impairment in short-term memory or concentration, sore throat, tender lymph nodes, muscle pain, multi-joint pain without swelling or redness, headaches of a new type, pattern or severity, unrefreshing sleep, and post-exertional malaise lasting more than 24 hours. National Center for Infectious Diseases CDC.

Study finds chronic fatigue clues in overactive immune response. Scientists exploring what may trigger chronic fatigue syndrome (CFS) have found clues in the way some people’ s immune systems respond more actively to a health attack. Reuters Health, 12/17/2018.

Symptoms of CFS

Cytokine signature associated with disease severity in chronic fatigue syndrome patients (CFS). The physicians explored the role of cytokine in CFS and they explained that most of the cytokines were proinflammatory and probably contributed to many of the symptoms of CFS. PubMed, Proc Natl Acad Sci U S A, 2017 Aug 22;114(34):E7150-E7158. (Also see Cytokines)

Symptoms of chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) are not determined by activity pacing when measured by the chronic pain coping inventory. Activity pacing does not appear to be a significant determinant of pain, fatigue or disability in people with CFS/ME when measured with the chronic pain coping index. Physiotherapy, 08/10/2017.

Treatments of CFS

Chronic fatigue syndrome treatments and drugs. Treatment for chronic fatigue syndrome focuses on symptom relief. Options include antidepressants, sleeping pills, graded exercise and psychological counseling. Mayo Clinic.

A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The unknown etiology of CFS/ME, and complications arising from its heterogeneous nature, contributes to the lack of clear evidence for pharmaceutical interventions. PubMed, 05/23/2016.

Relationship Between (CFS) and Fibromyalgia (FMS)

Fibromyalgia and Chronic Fatigue Information on the relationships between the rheumatological condition known as fibromyalgia, fibrositis, or FMS, chronic fatigue syndrome, CFS, myalgic encephalitis, ME, hypometabolism and thyroid disease, including hypothyroidism. VeryWell.

Neurological Disorders

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome (CFS). This study is the first to report that brain structural differences are associated with unrefreshing sleep in CFS and this result refutes the suggestion that unrefreshing sleep is a misperception in CFS patients and further investigation of this symptom is warranted. PubMed, NMR Biomed, 06/29/2017.

Cognitive Dysfunction in Chronic Fatigue Syndrome (CFS): a Review of Recent Evidence. The development of a brief neurocognitive battery specifically tailored to CFS and adoption by the international research community would be beneficial in establishing a profile of cognitive dysfunction. PubMed, Curr Rheumatol Rep, 2016 May;18(5):24.

Postural Orthostatic Tachycardia Syndrome (POTS)

Cognitive impairments associated with CFS and POTS. Future research should continue to examine possible explanations for cognitive impairments in CFS and POTS, and ultimately use this information to try and reduce cognitive impairments for these patients. Front. Physiol.


Neural signature for fibromyalgia may aid diagnosis, treatment. A brain signature that identifies fibromyalgia sufferers with 93 percent accuracy has been discovered by researchers, a potential breakthrough for future clinical diagnosis and treatment. Science Daily, 10/17/2016.

Disability Information for Chronic Fatigue Syndrome

CFS/FMS Objective Medical Evidence Requirements for Disability Adjudication Regarding Social Security Disability in the U.S. Susan M. Daniels, Ph. D.

CFS Stories

Beverly: CREST Scleroderma I was overtired and needed naps in the afternoon, pain was slowly getting the better of me and I finally went to the doctor…

Krisha S: Multiple Autoimmune Condition I have multiple sclerosis (MS), fibromyalgia, and Stiff Person Syndrome…

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