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Myopathy and Myositis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Myopathy vs. Myositis
Myopathies and Scleroderma
Myopathies and Overlapping Diseases

Myopathy vs. Myositis

Myopathy means muscle disease. Myositis means muscle disease that is caused by inflammation. There are three types of myositis: dermatomyositis, polymyositis, and inclusion body myositis. (Also see Autoimmune Diseases, and Dermatomyositis/Polymyositis)

Myopathies. Myopathy is the medical term for muscle disease. There are many causes of muscle disease, such as infection, muscle injury due to medications, inherited diseases affecting muscle function, disorders of electrolyte levels, and thyroid disease. Some of these disorders, such as polymyositis, dermatomyositis and inclusion body myositis, develop when the immune system attacks muscles. The primary symptom of myopathies is muscle weakness. American College of Rheumatology.

Myositis. Myositis is inflammation of your skeletal muscles, which are also called the voluntary muscles. These are the muscles you consciously control that help you move your body. An injury, infection or autoimmune disease can cause myositis. The diseases dermatomyositis and polymyositis both involve myositis. MedlinePlus.

Myopathies and Scleroderma

Muscle involvement in systemic sclerosis: points to consider in clinical trials. Outcome measures should include a combination of elements that are likely to be reversible, such as muscle weakness, biopsy–proven active inflammation, creatinine kinase/aldolase and a quality of life questionnaire. PubMed, Rheumatology (Oxford), 2017 Sep 1;56(suppl_5):v38-v44.

Systemic sclerosis–related changes on nailfold videocapillaroscopy (NC) in genetic and metabolic myopathies. These results suggest that other diseases, namely genetic and metabolic myopathies, should be considered when faced with SScs–like NC changes, including giant capillaries. Rheumatology (Oxford), 2016 Oct;55(10):1911-2. (Also see Nailfold Capillaroscopy)

Case Report: Systemic sclerosis and myositis as a paraneoplastic syndrome secondary to multiple myeloma (MM). To the best of our knowledge, this is the first case reporting these two clinical conditions simultaneously associated with MM. PubMed, Acta Reumatol Port. (Also see Cancer)

Case Report: Spontaneous pneumomediastinum in limited cutaneous systemic sclerosis and myositis overlap. A 58-year-old man with limited cutaneous systemic sclerosis and myositis overlap complicated by interstitial lung disease presented with several months of progressive dyspnoea and weakness. PubMed, BMJ Case Rep.

Cardiac troponin (cTnT) testing in idiopathic inflammatory myopathies and systemic sclerosis–spectrum disorders: biomarkers to distinguish between primary cardiac involvement and low–grade skeletal muscle disease activity. We propose two pragmatic clinical pathways using cardiac troponins to screen patients for subclinical cardiac disease and/or low-grade skeletal muscle disease activity. PubMed, Ann Rheum Dis. (Also see Prognosis and Mortality)

Clinical and laboratory features of overlap syndromes (OS) of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. This is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. PubMed, Clin Rheumatol. (Also see Scleroderma in Overlap)

Myopathies and Overlapping Diseases

Eosinophilic fasciitis associated with myositis: Report of four cases and review of the literature. We describe four patients who developed eosinophilic fasciitis, three of whom developed eosinophilic fasciitis with myositis. PubMed, Australas J Dermatol, 12/27/2018. (Also see Eosinophilic Fasciitis)

Advances in the early diagnosis and therapy of inclusion body myositis (IBM). Antibody testing and muscle imaging results may improve our ability to diagnose IBM and the availability of effective disease modifying treatments could soon become a reality. PubMed, Curr Opin Rheumatol, 07/31/2018.

Statin–related myopathies. Statin–induced immune–mediated necrotising myopathy represents a novel disease mechanism and clinically mimics forms of myositis. PubMed, Pract Neurol, 2018 Apr;18(2):97-105. (Also see Statins)

Relevance of ultrasonography in assessing disease activity in patients with idiopathic inflammatory myopathies. A mixture of muscle edema and atrophy was detected depending on disease activity and duration. PubMed, Int J Rheum Dis, 08/07/2017.

Assessment of Mortality in Autoimmune Myositis With and Without Associated Interstitial Lung Disease. Our results suggest that ILD remains an important and significant source of mortality in patients with inflammatory myopathies and as such should be screened for and treated aggressively. PubMed, Lung, 2016 Oct;194(5):733-7.

Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or rheumatoid arthritis (RA). The clinical manifestations of dermatomyositis/polymyositis were identified simultaneously with SSc and RA in the majority of cases, in contrast to identification in the SLE group. PubMed, Clin Rheumatol. (Also see Lupus in Overlap and Rheumatoid Arthritis in Overlap

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