Causes of Diabetes

Janey WillisHello, I am Janey Willis, ISN Guide to Diabetes. Type 1 Diabetes is an autoimmune disease, and Type 2 Diabetes is caused by risk factors such as lifestyle, ethnicity, age, and pregnancy. The majority of diabetics have Type 2. See Disclaimer.

Overview of Causes of Diabetes
Environmental Factors
Physiological Factors

Overview of the Causes of Diabetes

Causes of Diabetes KaleidoscopeCauses of diabetes includes genetic, environmental, and lifestyle factors. Risk factors for Type 2 Diabetes include obesity, inactivity, poor diet, age, ethnicity, and pregnancy. (Also see Autoimmune Diseases and Overview of Diabetes)


T-Cell Costimulation — Biology, Therapeutic Potential, and Challenges. CTLA-4 is involved in the induction and maintenance of T-cell tolerance. CTLA-4 polymorphisms in humans have been linked to susceptibility to autoimmune diseases, including type 1 diabetes and autoimmune thyroid disease. The New England Journal of Medicine. Vol 355:973-975,10. [2006]. (Also see Causes of Scleroderma: T-Cells and Thyroid Disease)

Environmental Factors

Diabetes: New pathway to treatment suggested by protein culprit. New research shows that a protein related to the development of anxiety and depression may also play a role in triggering diabetes. Medical News Today, 12/18/2017.

Sitting Really Can Kill You, Heart Experts Say. Evidence is building that sitting for too long can cause heart disease and diabetes – even in people who exercise, the American Heart Association said Monday. NBC News, 08/15/2016. (Also see Cardiac (Heart) Involvement)


Research Finds Shared Genetic Susceptibility for Celiac Disease and Type 1 Diabetes - Celiac Disease Awareness Campaign. A genetic susceptibility to both type 1 diabetes and celiac disease shares common alleles which suggests that common biological mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiological features of both diseases. National Institute of Diabetes and Digestive and Kidney Diseases.

Physiological Factors

Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus (T2DM). Reduced muscle mass and increased visceral fat are independently associated with increased arterial stiffness in postmenopausal women with T2DM. Diabetes Research and Clinical Practice, 11/05/2016.


Innate Viral Receptor Signaling Determines Type 1 Diabetes (T1D) Onset. Sensing of viral antigens by retinoic acid–inducible gene I–like receptors and toll–like receptors may be detrimental to inducing autoreactivity initiated by viral stress and resulting in T1D. PubMed, Front Endocrinol (Lausanne), 2017 Sep 26;8:249.

Go to Diagnosis of Diabetes

Many thanks to our recent donors, Network for Good. See ISN News for more donors. Click Here to Donate.


TOLL FREE HOTLINE, U.S. and Canada: 1-800-564-7099
Ask for our Free Info Packet by email or postal mail!

SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses.

We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected] to request our Welcome email, report bad links, or update page content. Disclaimer. Privacy Policy.

The most important thing in the world to know about scleroderma is!