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Treatments for Diabetes

Janey WillisHello, I am Janey Willis, ISN Guide to Diabetes. Type 1 Diabetes is an autoimmune disease, and Type 2 Diabetes is caused by risk factors such as lifestyle, ethnicity, age, and pregnancy. The majority of diabetics have Type 2. See Disclaimer.

Overview of Treatments
Treatments for Complications
Hormones
Insulin
Managing Diabetes
Pancreas and Islet Transplants
Stem Cell Transplant

Overview of Treatments for Diabetes

Treatment for Diabetes KaleidoscopeAll people with Type 1 Diabetes need to take insulin because their bodies do not make enough of it. Managing diabetes with diet and exercise is also important. In some cases, pancreas transplants or islet transplantation are considered to control one's diabetes. (Also see Autoimmune Diseases and Overview of Diabetes)

Treatments. This resource is designed to be used with forms that you can print out and personalize to meet your individual needs. National Diabetes Information Clearinghouse.

Treatments for Complications of Diabetes

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial. Our results suggest the concept that IL-1 inhibition may be considered a targeted treatment for RA and T2D. PubMed, PLoS Med, 2019 Sep 12;16(9):e1002901. (Also see Treatments for Rheumatoid Arthritis)

Autologous Bone Marrow–Derived Stem Cells (BMC) for Treating Diabetic Neuropathy in Metabolic Syndrome. In this review, we discuss the clinical practice in diabetic neuropathy and the therapeutic effect of BMC. PubMed, Biomed Res Int, 2017;2017:8945310.

Hormones

Vitamin D fights cancers and diabetes, is the pivotal feedstock for a hormone that protects muscle, and inhibits autoimmune disorders from multiple sclerosis and lupus to inflammatory bowel disease. Expired article from Science News Online [2005]. (Also see Causes of Scleroderma: Vitamin D Deficiency)

Insulin

Long-Term Efficacy and Safety of Sensor Augmented Insulin Pump (SAP) Therapy with Low-Glucose Suspend (LGS) Feature in Patients with Type 1 Diabetes (T1D). SAP+LGS therapy in T1D patients with hypoglycemia led to a significant and sustained decrease in glycated hemoglobin during long periods of follow-up, as well as a significant reduction in severe hypoglycemia and hypoglycemia unawareness. PubMed, Diabetes Technol Ther, 2017 Feb;19(2):109-114.

Managing Diabetes

Diabetes: How lifestyle and daily routine affect blood sugar. You can keep your blood sugar within target range and prevent diabetes complications by knowing what makes your blood sugar rise and fall. Take a look at the day-to-day factors that can cause your blood sugar to rise and fall. Then find out how to cope with them. MayoClinic.

Fish oil pills 'no benefit' for type 2 diabetes. People with type 2 diabetes "should not be encouraged" to take omega-3 fish oil supplements, researchers from the University of East Anglia say. BBC Health News, 08/22/2019. (Also see Supplement Guide)

Under pressure in diabetes, Novo Nordisk steps up focus on obesity drugs. The world’s largest maker of diabetes drugs said it would aim to develop medicines that treat obesity – a major cause of diabetes – at least as effectively as surgery. Reuters Health, 11/21/2017.

How Weight Loss Can Reverse Type 2 Diabetes. An analysis published in The BMJ aims to let doctors and the public in on a little–known secret: Type 2 diabetes, in many cases, is curable. Time Healthland, 09/13/2017.

Pancreas and Islet Transplants

Glycemic variability indices can be used to diagnose islet transplantation (IT) success in type 1 diabetic patients. The proposed thresholds allow an easy evaluation of IT success using only continuous glucose monitoring data and may be a clinical tool for the follow-up of transplanted patients. PubMed, Acta Diabetol, 10/10/2019.

Beta–cell therapies for type 1 diabetes: Transplants and bionics. This article reviews the current state of beta–cell replacement through transplant of the whole pancreas or of islet cells. PubMed, Cleve Clin J Med, 2018 Dec;85(12):931-937.

Long–term diabetes complications after pancreas transplantation. In patients with type 1 diabetes, pancreas transplantation may improve cardiac outcomes and ameliorate diabetic lesions in the kidney transplant. PubMed, Curr Opin Organ Transplant, 06/08/2017.

Stem Cell Transplants

Using Mesenchymal Stromal Cells in Islet Transplantation. This approach has the potential to overcome many of the technical and regulatory hurdles associated with using MSCs as an adjuvant therapy for human islet transplantation. PubMed, Stem Cells Transl Med, 2018 Aug;7(8):559-563.

Doctors discover new method to heal painful diabetic ulcers using a jab of 'muffin top' fat. Doctors have discovered an ingenious use for the excess fat — they are using it in injections for painful foot ulcers that are difficult to treat. Mail Online, 12/02/2017. (Also see Treatments for Digital Ulcers)

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