Treatments for Fibromyalgia (FMS)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Alternative Therapies
Cognitive Therapy
Low Level Laser
Peripheral Nerve Stimulation
Transcranial Stimulation


Participating in clinical trials can give patients access to newly emerging treatments for fibromyalgia and help scientists find a cure. (Also see Autoimmune Diseases, and Overview of Fibromyalgia and Chronic Fatigue Syndrome)

Clinical Trials: Fibromyalgia. A list of current and new clinical trials in the United States on Fibromyolgia. Center Watch.

Alternative Therapies

A new approach to the improvement of quality of life in fibromyalgia (FMS): a pilot study on the effects of an aquatic Ai Chi program. A water–based Ai Chi program may contribute to the improvement of mental and physical health and the quality of life in women with FMS. PubMed, Int J Rheum Dis, 07/26/2016.

Effects of music on pain in patients with fibromyalgia. The effect of music has been found to control pain in fibromyalgia patients and music therapy should be suggested in pain management for fibromyalgia patients as an non-pharmacologic nursing intervention. PubMed, Clin Rheumatol, 2016 May;35(5):1317-21.

Cognitive Therapy

Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in the Treatment of Fibromyalgia: A Randomised Trial. Depressive symptoms and the impact of the illness were reduced and maintained in the MBCT group of women diagnosed with fibromyalgia. No significant changes were found in the reduction of intensity of pain. Cognitive Therapy and Research.


Association of patterns of moderate–to–vigorous physical activity (MVPA) bouts with pain, physical fatigue and disease severity in women with fibromyalgia: the al–√Āndalus project. The results suggest that longer bouts of continuous MVPA are associated with better symptoms profile in this population, which needs to be corroborated in longitudinal research. PubMed, Arch Phys Med Rehabil, 01/05/2019.

Resistance exercise improves physical fatigue in women with fibromyalgia: a randomized controlled trial. Person–centered progressive resistance exercise improved physical fatigue in women with FM when compared to an active control group. Bio Med Central, Arthritis Research & Therapy, 07/30/2016.

Low Level Laser

Low–level laser therapy (LLLT) and anesthetic infiltration for orofacial pain in patients with fibromyalgia (FM): a randomized clinical trial. The LLLT by Gallium–Aluminum–Arsenide (GaAlAs) and anesthetic infiltration of lidocaine 2% were equally effective to control orofacial pain in FM individuals. PubMed, Med Oral Patol Oral Cir Bucal, 2018 Jan 1;23(1):e65-e71.


How is Fibromyalgia Treated? Three medicines have been approved by the U.S. Food and Drug Administration (FDA) to treat fibromyalgia. These are pregabalin (Lyrica), duloxetine (Cymbalta), and milnacipran (Savella). MedicineNet.

Hope for fibromyalgia sufferers as experts discover common diabetes drug “eradicates pain”. Fibromyalgia and other forms of chronic pain may be caused by insulin resistance, groundbreaking new research suggests. The Sun, 05/08/2019.

Patients' perspective of the effectiveness and acceptability of pharmacological and non–pharmacological treatments of fibromyalgia. This article presents results from a large online survey on fibromyalgia patient perspectives of pharmacological and non–pharmacological treatments. PubMed, Scand J Pain, 10/13/2018.

The relationship of endocannabinoidome lipid mediators with pain and psychological stress in women with fibromyalgia (FM)– a case control study. This study reports about elevated plasma levels of endocannabinoidome lipid mediators in FM. PubMed, J Pain, 06/06/2018. (Also see Endocannabinoid System)

Cannabinoids and autoimmune diseases: A systematic review. Cannabinoids are effective as treatment for fibromyalgia and have shown to have anti–fibrotic effect in scleroderma. PubMed, Autoimmun Rev, 2016 Jun;15(6):513-28. (Also see Endocannabinoid System)

Peripheral Nerve Stimulation

Pain Management and Nerve Blocks. Nerve blocks are sometimes highly effective in providing temporary relief for muscle and joint pain caused by fibromyalgia.WebMD.

Transcranial Direct Current Stimulation (tDCS)

Is high–frequency repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex superior to the stimulation of the left dorsolateral prefrontal cortex in fibromyalgia syndrome? Significant improvements in physical role functioning, physical functioning, depression, and general health perceptions were achieved in active rTMS groups. PubMed, Somatosens Mot Res, 2019 Apr 8:1-7.

Adding Prefrontal Transcranial Direct Current Stimulation (tDCS) Before Occipital Nerve Stimulation (ONS) in Fibromyalgia. This study suggests that adding right–anode bifrontal tDCS to ONS has no added benefit in improving fibromyalgia–related symptoms. PubMed, Clin J Pain, 2018 May;34(5):421-427.

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