Viruses and Bacteria
Increased lipid and protein oxidation and lowered anti–oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules. Increased nitro–oxidative stress takes part in the (auto)immune pathophysiology of SLE and modulates severity of illness and adhesion molecule expression. PubMed, Immunol Res, 11/29/2017.
Activating and inhibitory receptors on natural killer cells in patients with systemic lupus erythematosis (SLE)–regulation with interleukin-15. Natural killer (NK) cells may play an important role in the pathogenesis of SLE. PubMed, PLoS One, 2017 Oct 12;12(10):e0186223. (Also see Natural Killer Cells)
A Stress Link to Lupus. Psychological trauma is associated with an increased risk for lupus, a new study reports. New York Times, 09/20/2017.
Immune complexes containing serum B-cell activating factor (BAFF) and immunoglobulin G (IgG) correlate with disease activity in systemic lupus erythematosus (SLE). BAFF–IgG complexes strongly correlate with disease activity in SLE patients, suggesting a pathogenic role in SLE. Nephrology Dialysis Transplantation, 08/08/2017.
Endothelial Alterations in Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA): Potential Effect of Monocyte Interaction. This paper aims to review some aspects about the endothelial activation and dysfunction in the context of SLE and RA, as well as the potential role that monocytes apparently play in this process. PubMed, Mediators Inflamm, 2017;2017:9680729. (Also see Causes of Rheumatoid Arthritis)
Expression of CCR6 on B cells in systemic lupus erythematosus patients. Pre–germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. PubMed, Clin Rheumatol, 2017 Jun;36(6):1453-1456. (Also see B Cells and T Cells)
Homocysteine (HHcy) serum levels are increased and correlate with disease severity in patients with lupus erythematosus (LE). Hcy levels were higher in patients with different forms of cutaneous LE and correlated with disease activity, therefore HHcy could be related to LE pathogenesis and might be a triggering factor in predisposed individuals. PubMed, Clin Exp Rheumatol, 01/08/2016.
New Genetic Mutation That Halts The Development Of Lupus Discovered. The lupus-suppressing action is the result of what is known as a nonsense mutation of the Coronin-1A gene (Coro1a) required for the development of the disease. ScienceDaily.
The interaction between environmental triggers and epigenetics in autoimmunity. Reactive oxygen species that inhibit Dnmt1 upregulation, and a diet poor in methyl donors, combine to cause lupus in animal models. PubMed, Clin Immunol, 04/09/2018.
Environmental exposures and the development of systemic lupus erythematosus. Identifying the environmental risk factors related to risk of SLE is essential as it will lead to increased understanding of pathogenesis of this complex disease and will also make risk factor modification possible for those at increased risk. PubMed, Curr Opin Rheumatol, 2016 Sep;28(5):497-505.
Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus (SLE). The concentration of IL-13 was significantly elevated in rs20541 CT/TT genotypes compared with CC genotype which suggests that rs20541 CT/TT genotypes may be a risk factor for SLE. PubMed, Cytokine, 10/07/2017. (Also see Interleukins)
Evaluation of polymorphic variants in apoptotic genes and their role in susceptibility and clinical progression to systemic lupus erythematosus. Our data support a role for apoptosis in SLE susceptibility. PubMed, Lupus, 11/30/2016.
Genetics of systemic lupus erythematosus (SLE) and Sjögren's syndrome: an update. SLE and Sjögren's syndrome are two closely related systemic autoimmune diseases that share multiple clinical and molecular aspects, including a significant number of susceptibility genes. PubMed,Curr Opin Rheumatol. 2016 Sep;28(5):506-14. (Also see Sjogren's Syndrome)
Hormonal Modulation of Dendritic Cells (DC) Differentiation, Maturation and Function: Implications for the Initiation and Progress of Systemic Autoimmunity. In this review, we discuss recent data relative to the role of different hormones (estrogen, prolactin, progesterone and glucocorticoids) in DC function during systemic autoimmune pathogenesis. PubMed, Arch Immunol Ther Exp (Warsz), 09/01/2016.
Contraception in patients with systemic lupus erythematosus and antiphospholipid syndrome. Contraceptive choice in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) is challenging but important. Long-acting forms of contraception such as the progesterone intrauterine device (IUD) or subdermal implant are preferable for most patients. Sage Journals, Lupus.
Systemic Lupus Erythematosus (SLE): Another Autoimmune Disorder Influenced by Microbes and Diet? In this review, the aim is to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis. PubMed, Front Immunol, 2015 Nov 30;6:608.
Correlation between systemic lupus erythematosus (SLE) and cytomegalovirus infection (CMV) detected by different methods. This data confirmed that the human CMV infection was related to the development of SLE. PubMed, Clin Rheumatol, 2015 Apr;34(4):691-8.
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