Lupus and MCTD
Lupus and Endometriosis
Lupus and Epstein–Barr Virus
Lupus and IBS
|Lupus and Myopathy
Lupus and Pancreatitis
Lupus and Scleroderma
Lupus and Sjogren's
Overlap Syndromes. Lupus can occur as just one part of overlap syndromes, including Mixed Connective Tissue Disease (MCTD). ISN.
|Overview of Polyautoimmunity
Scleroderma in Overlap
Connective Tissue Disease (CTD)
Mixed Connective Tissue Disease (MCTD)
|Multiple Autoimmune Syndrome
Undifferentiated Connective Tissue Disease (UCTD)
Overlap Patient and Caregiver Stories
Endometriosis and systemic lupus erythematosus (SLE): a population-based case–control study. Findings suggest an association between endometriosis and SLE and studies with extended follow–up will be necessary to clarify whether this association is influenced by the timing and severity of endometriosis diagnosis. Sage Journals, Lupus 02/06/2016.
How compelling are the data for Epstein–Barr virus (EBV) being a trigger for systemic lupus (SLE) and other autoimmune diseases? Collectively, the interplay between an impaired immune system and the cumulative effects of EBV and other viruses results in frequent reactivation of EBV and enhanced cell death. PubMed, Curr Opin Rheumatol, 2016 Jul;28(4):398-404.
Irritable bowel syndrome (IBS)-type symptoms in female patients with mild systemic lupus erythematosus (SLE): frequency, related factors and quality of life. IBS-type symptoms are highly prevalent among women with SLE and are associated with fibromyalgia (FM) and depression. SLE+IBS patients had worse quality of life (HRQOL) vs Non-IBS SLE, independently of FM status. Treating IBS symptoms may improve HRQOL in women with SLE. PubMed, Neurogastroenterol Motil. (Also see Fibromyalgia, and Depression)
Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or rheumatoid arthritis (RA). The clinical manifestations of dermatomyositis/polymyositis were identified simultaneously with SSc and RA in the majority of cases, in contrast to identification in the SLE group. PubMed, Clin Rheumatol. (Also see Rheumatoid Arthritis in Overlap and Myopathy and Myositis)
Prevalence, severity, and clinical features of acute (AP) and chronic pancreatitis (CP) in patients with systemic lupus erythematosus. There were significant differences in the clinical manifestations of AP and CP and patients with severe AP were found to have a higher incidence of concomitant infection and serum triglyceride levels. PubMed, Rheumatol Int, 07/05/2016. (Also see Pancreatitis)
Olfactory function in systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). A longitudinal study and review of the literature. Both SLE and SSc patients with longstanding disease had significant reduction in all stages of the Sniffin' Sticks test (TDI) that maintained stable over a 2–year period. PubMed, Autoimmun Rev, 02/11/2018. (Also see Brain Involvement)
When lupus and Sjogren's occur together, it can indicate a milder course for both diseases. Older white females are more vulnerable to this overlap, and they tend to have sun sensitivity, oral ulcers, Raynaud's, and certain antibodies.
Two subgroups in systemic lupus erythematosus (SLE) with features of antiphospholipid (APS) or Sjögren's syndrome (SS) differ in molecular signatures and treatment perspectives. Stratifying SLE patients based on an autoantibody profile could be a way forward to understand underlying pathophysiology and to improve selection of patients for clinical trials of targeted treatments. PubMed, Arthritis Res Ther, 2019 Feb 18;21(1):62. (Also see Sjögren's Syndrome and Antiphospholipid Syndrome)
Comorbidities in patients with Primary Sjögren's Syndrome (pSS) and Systemic Lupus Erythematosus (SLE): A comparative registries–based study. pSS patients have consistently less serious cardiovascular comorbidity burden and a lower prevalence of severe infection than those with SLE, although in contrast, their risk of lymphoma was greater. PubMed, Arthritis Care Res (Hoboken), 08/26/2016. (Also see Sjögren's Syndrome)
We have the world's best supporters! See ISN News.
SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses. We are a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team. Donations may also be mailed to: