Quality of Life
Areas of the most intense research for lupus include genetics, and treatments. Every lupus patient should have their Vitamin D status regularly tested and their levels optimized. (Also see Autoimmune Diseases, Overview of Lupus, Difficult Diagnosis, What is Scleroderma?, and Overlap Syndrome)
Correlation between the changes of innate lymphoid cells (ILCs) in peripheral blood of systemic lupus erythematosus (SLE) and its clinical significance. The percentage of ILCs is related to disease activity, and ILCs play a “double-edged” role in the pathogenesis of SLE. PubMed, Zhonghua Yi Xue Za Zhi, 2019 Jan 15;99(3):169-173.
Progressive reduction of serum complement levels: a risk factor for relapse in patients with hypocomplementemia in systemic lupus erythematosus (SLE). Simultaneous progressive reductions in complement levels and increases in anti-dsDNA antibody levels may indicate future relapse of serologically active clinically quiescent–SLE patients. PubMed, Lupus, 2018 Oct 11:961203318804892.
Adipokine interactions promote the pathogenesis of systemic lupus erythematosus (SLE). Adipokines levels and associated clinical manifestations suggest involvement of adipokines in disease pathogenesis of SLE. PubMed, Cytokine, 2018 Aug 8;111:20-27.
Full high–throughput sequencing analysis of differences in expression profiles of long noncoding RNAs and their mechanisms of action in systemic lupus erythematosus. This work determined specific lncRNAs that play important biological functions in the pathogenesis of lupus and provided a new direction for diagnosis and treatment of disease. PubMed, Arthritis Res Ther, 2019 Mar 5;21(1):70.
The Synergistic Effect of TNFA and IL10 Promoter Polymorphisms on Genetic Predisposition to Systemic Lupus Erythematosus (SLE). Our findings suggest that the combinatorial complexity of TNFA and IL10 promoter polymorphisms impacts SLE susceptibility. PubMed, Genet Test Mol Biomarkers, 01/03/2018.
Advances in Microbiome Detection Technologies and Application in Antirheumatic Drug Design.We review the altered gut microbiota signatures that have been reported so far across various studies, upon which diagnostics classification models can be constructed. PubMed, Curr Pharm Des, 12/10/2020.
Microbiome and Metabolome Analyses Reveal the Disruption of Lipid Metabolism in Systemic Lupus Erythematosus (SLE). Our results illustrate the perturbation of the gut microbiome and metabolome in SLE patients which may facilitate the development of new SLE interventions. PubMed, Front Immunol, 2020 Jul 31;11:1703. (Also see Causes of Lupus)
IFN-I Mediates Dysfunction of Endothelial Progenitor Cells in Atherosclerosis of Systemic Lupus Erythematosus (SLE). This paper reviews the latest SLE epidemiology and pathogenesis. PubMed, Front Immunol, 2020 Nov 11;11:581385.
miR-210 expression in PBMCs from patients with systemic lupus erythematosus and rheumatoid arthritis. The dysregulation of miR-210 levels in SLE and RA patients suggests that miR-210 might play an important role in the pathogenesis of these diseases. PubMed, Ir J Med Sci,2018 Feb;187(1):243-249. (Also see Symptoms and Complications of Rheumatoid Arthritis)
Y-27632, a Rho–associated protein kinase inhibitor, inhibits systemic lupus erythematosus. The findings showed that the inhibition of rho-associated, coiled–coil–containing protein kinase 1(ROCK) was beneficial for the prevention of systemic lupus erythematosus, which possibly by suppressing NF-?B activation. PubMed, BioMed Pharmacother. (Also see Interleukins)
Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). Functional LILRA3 is a new susceptibility factor for SLE and pSS and it highly predisposes to certain phenotypes such as leucopenia, thrombocytopenia and autoantibody-positive subphenotypes. PubMed, Ann Rheum Dis. (Also see Sjögren's Syndrome Research)
Prevalence and metric of depression and anxiety in systemic lupus erythematosus: a systematic review and meta–analysis. There was high variability in the prevalence of depression and anxiety, ranging from 8.7%-78.6% and 1.1%-71.4%, respectively. PubMed, Semin Arthritis Rheum, 2020 Feb;50(1):84-94. (Also see Anxiety and Attitude)
Vitamin D receptor (VDR) and monocyte chemoattractant protein-1 expressions in peripheral blood mononuclear cells (PBMC) in patients with systemic lupus erythemaotsus (SLE). The down-regulation of VDR expression in the PBMC is negatively correlated with the disease activity of SLE. PubMed, Nan Fang Yi Ke Da Xue Xue Bao, 2020 Jan 30;40(1):99-103.
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