Myasthenia Gravis (MG)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
What is Myasthenia Gravis?
Symptoms of MG
Pregnancy and MG
Scleroderma and MG
Treatments for MG
Research about MG
Personal Stories about MG

What is Myasthenia Gravis?

Myasthenia Gravis Kaleidoscope Myasthenia gravis is a rare autoimmune disease that affects voluntary muscles, causing them to weaken with activity.

Myasthenia gravis is a neuromuscular disorder characterized by variable weakness of voluntary muscles, which often improves with rest and worsens with activity. The condition is caused by an abnormal immune response. Medline Plus Dictionary.

Myasthenia gravis may be associated with other autoimmune diseases. Patients with family members who suffer from disorders such as rheumatoid arthritis, scleroderma, and lupus may have an increased risk for myasthenia gravis. Neurology Channel.

Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. National Institute of Neurological Disorders and Stroke.

Myasthenia Gravis Myasthenia gravis (MG) is the most common primary disorder of neuromuscular transmission. Myasthenia Gravis Foundation of America and James F. Howard, Jr., M.D.

Myasthenia Gravis. Medline Plus Health Information.

Case Report: Ocular myasthenia gravis in a person with tetraplegia presenting challenges in diagnosis and management. We report the first case of ocular myasthenia gravis in a patient with complete tetraplegia, highlighting diagnostic and management challenges. PubMed, Spinal Cord Ser Cases.

Neuropsychological performance in patients with myasthenia gravis. Neuropsychological performance declines in patients with myasthenia gravis: attention was more affected than other cognitive areas. PubMed, Medicina (B Aires), 2017;77(2):117-120.

Symptoms of Myasthenia Gravis

Symptoms of Myasthenia Gravis The primary symptoms of myasthenia gravis are that muscles are weak and quick to fatigue. These symptoms can take many forms, and the symptoms may be more or less severe for different people. Aetna InteliHealth.

A quantitative method for the assessment of dysarthrophonia in myasthenia gravis (MG). This study demonstrates that non–invasive physiological methods (electroglottography and speech acoustics) offer essential tools for the assessment of dysarthrophonia in MG patients. PubMed, J Neurol Sci, 2017 Jun 15;377:42-46.

Pregnancy and Myasthenia Gravis

Myasthenia Gravis (MG) may be associated with other autoimmune diseases. Patients with family members who suffer from disorders such as rheumatoid arthritis, scleroderma, and lupus may have an increased risk for myasthenia gravis. (Also see What is Scleroderma?)

Successful use of sugammadex for caesarean section in a patient with myasthenia gravis. Myasthenia gravis especially when associated with pregnancy is a high–risk disease, and its course is unpredictable. The use of sugammadex after rocuronium for a caesarean delivery was successful. PubMed, Rev Bras Anestesiol, 01/10/2017.

Increased risk for clinical onset of myasthenia gravis (MG) during the postpartum period. Women have a high-risk period for the onset of clinical symptoms of MG in the postpartum period, in particular after the first childbirth. PubMed, Neurology. 2016 Nov 15;87(20):2139-2145.

Scleroderma and Myasthenia Gravis

Myasthenia gravis and scleroderma: Two cases and a review of the literature. Myasthenia gravis is uncommon in patients with scleroderma, and when diagnosed is usually associated with previous use of d-penicillamine. Clinically, both myasthenia and scleroderma may present with fatigue, weakness and bulbar symptoms, so one of diagnoses may be delayed. PubMed, Clin Neurol Neurosurg. (Also see Clinical Trials: Negative Results)

Myasthenia Gravis (MG) may be associated with other autoimmune diseases. Patients with family members who suffer from disorders such as rheumatoid arthritis, scleroderma, and lupus may have an increased risk for myasthenia gravis. (Also see Autoimmune Diseases: Main Page and What is Scleroderma?)

Treatments for Myasthenia Gravis

Specific removal of autoantibodies by extracorporeal immunoadsorption ameliorates experimental autoimmune myasthenia gravis. Plasmapheresis and IgG–immunoadsorption are useful therapy options, but are highly non–specific. PubMed, J Neuroimmunol, 09/06/2017. (Also see Therapeutic Plasma Exchange)

An update on treatments in myasthenia gravis (MG). This is a small but promising pilot study demonstrating that leflunomide may be an efficacious and safe steroid–sparing immunosuppressant for MG. PMC, J Neurol, 2017; 264(1): 205–207.

Improvement of quality of life after therapeutic plasma exchange in patients with myasthenic crisis. Therapeutic plasma exchange significantly improves the quality of life of patients with myasthenia gravis during the crisis. PubMed, Neurol Neurochir Pol, 2016 Nov - Dec;50(6):418-424. (Also see Therapeutic Plasma Exchange)

Research about Myasthenia Gravis

The role of TNFα induced protein 3 interacting protein 1(TNIP1) in the pathogenesis of myasthenia gravis among patients with thymoma. Reduced TNIP1 expression may have a role in the pathogenesis of MG for patients with thymoma and thymectomy may help to recover the expression of TNIP1 among such patients. PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2016 Oct;33(5):615-8.

Personal Stories about Myasthenia Gravis

Papa V: Lupus, Antiphospholipid Syndrome, Myasthenia Gravis, and Scleroderma About thirty years passed, and then—BAM !—I got a heart blockage, stroke, liver biopsy due to elevated enzymes, skin rash, high blood pressure, very high ANA..

Go to Autoimmune Pancreatitis

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