SCLERO.ORG
Search
SCLERO.ORG is retiring 4-24-2021. Thank you for the memories! You'll still find us in the Wayback Machine, and we'll carry your stories in our hearts forever.

Causes of Rheumatoid Arthritis

Overview
Antibodies
Environmental Exposures
Fibroblasts
Genetics
Gut Bacteria
Lifestyle
Sleep Disorders

Overview

Causes of Rheumatoid Arthritis. It's likely that rheumatoid arthritis occurs as a result of a complex combination of factors, including your genes, your lifestyle choices, such as smoking, and things in your environment, such as viruses. MayoClinic.

Interleukin-6 in Rheumatoid Arthritis (RA). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA. PubMed, Int J Mol Sci, 2020 Jul 23;21(15):5238. (Also see Interleukins)

Endothelial activation and injury by microparticles (MPs) in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). MPs and MPs-immune complexes from patients with SLE and RA increase adhesion molecules expression, chemokine production, and structural alterations in macrovascular and microvascular endothelial cells. PubMed, Arthritis Res Ther, 2019 Jan 23;21(1):34. (Also see Causes of Lupus)

The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis. All IL-20 family members utilize the Janus kinase signaling pathway and are therefore potentially inhibited by drugs targeting these enzymes. PubMed, Front Immunol, 2018 Sep 25;9:2226. (Also see Interleukins)

Antibodies

Serum–soluble folate receptor β (sFRβ) as a biomarker for the activity of rheumatoid arthritis synovitis and the response to anti-TNF agents. The findings support that high serum sFRβ levels act as a predictive biomarker for the response to anti-TNF agents. PubMed, Clin Rheumatol, 2018 Nov;37(11):2939-2945.

Sputum Anticitrullinated Protein Antibodies in Patients With Long–standing Rheumatoid Arthritis (RA). Anticitrullinated protein/peptide antibodies can be detected in the sputum of RA patients and are correlated with the presence in the serum. PubMed, J Clin Rheumatol, 2018 Apr;24(3):122-126.

Moderate use of alcohol is associated with lower levels of C reactive protein (CRP) but not with less severe joint inflammation: a cross-sectional study in early Rheumatoid Arthritis (RA) and healthy volunteers. Despite the fact that moderate alcohol consumption has been shown protective against RA, and our data confirm a J-shaped association of alcohol consumption with CRP levels in RA, alcohol was not associated with the severity of joint inflammation. PubMed, RMD Open, 2018 Jan 7;4(1):e000577. (Also see Antibodies)

Autoantibodies (AAbs) against interleukin-21 correlate with disease activity in patients with rheumatoid arthritis (RA). The levels of AAbs against IL-21 correlate with disease activity, which suggests that anti–IL-21 AAbs may play a role in the pathogenesis of RA. PubMed, Clin Rheumatol, 2018 Jan;37(1):75-80. (Also see Interleukins)

Environmental Exposures

The importance of differences; On environment and its interactions with genes, and immunity in the causation of rheumatoid arthritis. The findings referred to in the review have led to a change of paradigms for very early therapy and prevention of RA. PubMed, J Intern Med, 03/16/2020.

Fibroblasts

MicroRNA-506 (miR-506) inhibits rheumatoid arthritis fibroblast–like synoviocytes proliferation and induces apoptosis by targeting TLR4. miR-506 may be a potential target for RA prevention and therapy of RA. PubMed, Biosci Rep, 04/11/2019.

Tetraspanin CD82 affects migration, attachment and invasion of rheumatoid arthritis synovial fibroblasts (RASF). CD82 could contribute to RASF migration to sites of inflammation and tissue damage, where CD82 keeps aggressive RASF on site. PubMed, Ann Rheum Dis, 07/06/2018.

Genetics

Associations between Polymorphisms in the IL-1 Gene and the Risk of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE): Evidence from a Meta-Analysis. This meta-analysis was performed to more robustly evaluate associations between polymorphisms in the IL-1 gene and the risk of RA/SLE. PubMed, Int Arch Allergy Immunol, 2020 Dec 7;1-9. (Also see Interleukins and Causes of Lupus)

Gut Bacteria

Gut bacteria linked to rheumatoid arthritis. Rheumatoid arthritis has confounded efforts to identify its trigger and mounting evidence points to a new suspect: a disturbance in the bacteria that live in the intestines. NIH Research Matters.

Lifestyle

Investigating asthma, allergic disease, passive smoke exposure, and risk of rheumatoid arthritis (RA). Asthma and allergies may be associated with increased risk of RA, although passive smoke exposure and earlier age of starting smoking do not appear to influence risk of RA. PubMed, Arthritis Rheumatol, 02/12/2019. (Also see Asthma)

Sleep Disorders

Subjective sleep disturbances at the time of diagnosis in patients with polymyalgia rheumatica (PMR) and in patients with seronegative elderly-onset rheumatoid arthritis (SEORA).. The study suggests that the assessment of subjective sleep disturbances can be useful in the differential diagnosis between recent-onset PMR and SEORA. PubMed, Reumatologia, 2020;58(4):196-201.

Go to Diagnosis of Rheumatoid Arthritis
 
 

SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses. We are a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected]. Disclaimer. Privacy Policy.