Diagnosis of Rheumatoid Arthritis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview Antibodies


Rheumatoid arthritis is generally diagnosed and treated by rheumatologists, in most countries.

B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. We demonstrate an ongoing B cell-rich synovitis in a larger proportion of patients with established RA that does not seem to be captured by standard clinimetric assessment. PubMed, Arthritis Rheumatol, 11/29/2019. (Also see B Cells and T Cells)

T cell receptor β repertoires (TCR) as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis. These characteristics of the TCR repertoire can potentially serve as biomarkers and provide novel insights for disease status and therapeutical targets in autoimmune diseases. PubMed, Ann Rheum Dis, 05/17/2019. (Also see Diagnosis of Lupus)

Effects of Vitamin D on disease activity and serum interleukin-6 in rheumatoid arthritis (RA). This study suggests that vitamin D is not associated with disease activity or serum IL-6 levels but it may have a role in functional disability in RA patients. PubMed, Int J Rheum Dis, 02/06/2019. (Also see Vitamin D)

C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid. The data support that the C5a-C5aR axis may be driving the infiltration of inflammatory cells into the synovial fluid and synovium in both rheumatoid and psoriatic arthritis, and suggest that C5a or C5aR may be a promising treatment target in both diseases. PubMed, PLoS One, 2017 Dec 8;12(12):e0189017.(Also see Psoriasis and Psoriatic Arthritis)

Circulating osteoprotegerin levels are elevated in rheumatoid arthritis (RA): a systematic review and meta–analysis. Our meta–analysis revealed a significantly higher circulating osteoprotegerin level in RA patients, and it was influenced by race, disease duration, body mass index and disease activity score based on the assessment of 28 joints. PubMed, Clin Rheumatol, 07/11/2017.

Autoimmunity as a trigger for structural bone damage in rheumatoid arthritis. At present, rheumatoid factor and antibodies recognizing citrullinated proteins are considered as potent osteoclast inducers and triggers for bone loss in arthritis. PubMed, Mod Rheumatol, 2017 Jan 9:1-5.

The role of ultrasound in diagnosing rheumatoid arthritis, what do we know? An updated review. The use of musculoskeletal ultrasound adds value in diagnosing early RA, especially in seronegative arthritis. PubMed, Rheumatol Int, 11/01/2016.

Serum level of neopterin is not a marker of disease activity in treated rheumatoid arthritis patients. The results indicated that neopterin is a marker of RA but not a marker of disease activity in treated RA patients. PubMed, Clin Rheumatol, 10/03/2016.

A new window of opportunity in rheumatoid arthritis: targeting at-risk individuals. The prospective study of at–risk individuals can provide invaluable aetiological insights as well as facilitating accurate risk prediction data and in this way, high–risk individuals may be identified for preventive interventions. PubMed, Curr Opin Rheumatol, 2016 May;28(3):260-6.

Differentiation between early rheumatoid and early psoriatic arthritis by the ultrasonographic (US) study of the synovio–entheseal complex of the small joints of the hands. The US involvement of synovio–entheseal complex and US extrasynovial features may be helpful in the differential diagnosis between early rheumatoid and early psoriatic arthritis. PubMed, Clin Exp Rheumatol, 03/03/2016. (Also see Psoriasis and Psoriatic Arthritis)

Rheumatoid Arthritis: Notable Biomarkers Linking to Chronic Systemic Conditions and Cancer. Due to the complex nature of the disease, the appearance of symptoms and markers vary amongst individuals and the connections may manifest only in part. PubMed, Curr Pharm Des, 2016;22(7):918-24. (Also see Cancer)

Antibodies of Rheumatoid Arthritis

Differential synovial tissue (ST) biomarkers among psoriatic arthritis and rheumatoid factor/anti–citrulline antibody–negative rheumatoid arthritis. Histological analysis of ST may help to solve the clinical overlap between the two diseases and provides prognostic data about the therapy success. PubMed, Arthritis Res Ther, 2019 May 9;21(1):116. (Also see Psoriasis and Psoriatic Arthritis)

Diagnostic value of anti–citrullinated fibrinogen antibody in rheumatoid arthritis (RA): A meta–analysis. The ACF antibody had a moderate diagnostic accuracy on RA. PubMed, Int J Rheum Dis, 02/06/2019.

Triple Positivity for Anti–Citrullinated Protein Autoantibodies (ACPAs), Rheumatoid Factor (RF), and Anti–Carbamylated Protein Antibodies (anti–carP) Conferring High Specificity for Rheumatoid Arthritis (RA): Implications for Very Early Identification of At–Risk Individuals. An autoantibody profile of triple positivity for ACPAs, RF and anti–CarP provides interesting information that might help identify individuals at risk of developing RA. PubMed, Arthritis Rheumatol, 2018 Nov;70(11):1721-1731.

Association between anti–citrullinated fibrinogen antibodies and coronary artery disease (CAD) in rheumatoid arthritis (RA). Anti–cit–fibrinogen antibodies as a group were associated with CAD outcomes in our RA cohort, with the strongest signal for association arising from a subset of the autoantibodies. PubMed, Arthritis Care Res (Hoboken), 10/08/2017.

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