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Rheumatoid Arthritis in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Orchids abstract painting by Janet PaulmennRheumatoid Arthritis in overlap is when RA is found with other autoimmune diseases or chronic illness.

RA is often found in overlap with other connective tissue diseases such as scleroderma, lupus, and polymyositis/dermatomyositis. It can also be found with other diseases such as thyroiditis, fibromyalgia, and sjogren's. (Also see What is Scleroderma?, Lupus, Dermatomyositis/Polymyositis, Thyroid Diseases, Fibromyalgia, Sjogren's, and Overlap Syndromes/MCTD/UCTD)

Joint damage is amplified in rheumatoid arthritis (RA) patients with positive thyroid autoantibodies (TAbs). Our data showed that joint destruction was amplified in RA patients with an elevated presence of TAbs, which supports the importance and necessity of TAbs and thyroid function screening and monitoring in RA patient management in clinical practice. PubMed, PeerJ, 2018 Jan 4;6:e4216. (Also see Autoimmune Thyroid Diseases)

Short–course tocilizumab (TCZ) increases risk of hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis: a prospective clinical observation. To identify the exact risk of TCZ on HBV infection and the prognosis of TCZ–related HBV reactivation, further studies with larger sample sizes and fewer confounding factors are needed. PubMed, Int J Rheum Dis, 02/03/2017. (Also see Clinical Trials and Liver Involvement)

Prevalence of hypothyroidism in rheumatoid arthritis and its correlation with disease activity. Thyroid function test should be included in clinical evaluation of RA patients. PubMed, Trop Doct, 2017 Jan;47(1):6-10. (Also see Thyroid Diseases)

Comorbidity in rheumatoid arthritis. As a part of strategies to improve further the management of patients with RA, multidisciplinary collaboration for prevention and early detection of comorbidities is of major importance. PubMed, Swiss Med Wkly, 2016 Apr 5;146:w14290.

The effect on treatment response of fibromyalgic (FRA) symptoms in early rheumatoid arthritis (RA) patients: results from the ESPOIR cohort. Patients with FRA and RA will have a similar response to treatment, but may miss the target of remission or low disease activity. PubMed, Rheumatology (Oxford), 07/17/2015. (Also see Treatments for Rheumatoid Arthritis)

Salivary Gland Ultrasonography (US) as a Diagnostic Tool for Secondary Sjögren Syndrome (sSS) in Rheumatoid Arthritis (RA). Salivary gland US may aid the diagnosis of sSS in patients with RA. PubMed, J Rheumatol, 05/01/2015. (Also see Diagnosis of Sjögrens)

Diabetes mellitus (DM) risk factors in rheumatoid arthritis (RA): a systematic review and meta-analysis. RA is associated with increased risk of DM, including T1DM and T2DM. PubMed, Clin Exp Rheumatol, Clin Exp Rheumatol, 2015 Jan-Feb;33(1):115-21. (Also see Symptoms and Complications of Diabetes)

Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or rheumatoid arthritis (RA). The clinical manifestations of dermatomyositis/polymyositis were identified simultaneously with SSc and RA in the majority of cases, in contrast to identification in the SLE group. PubMed, Clin Rheumatol. (Also see Lupus in Overlap and Myopathy and Myositis)

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