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Rheumatoid Arthritis in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Orchids abstract painting by Janet PaulmennRheumatoid Arthritis in overlap is when RA is found with other autoimmune diseases or chronic illness.

RA is often found in overlap with other connective tissue diseases such as scleroderma, lupus, and polymyositis/dermatomyositis. It can also be found with other diseases such as thyroiditis, fibromyalgia, and sjogren's. (Also see What is Scleroderma?, Lupus, Dermatomyositis/Polymyositis, Thyroid Diseases, Fibromyalgia, Sjogren's, and Overlap Syndromes/MCTD/UCTD)

Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Subsequent Risk for Incident Rheumatoid Arthritis (RA) among Women: A Prospective Cohort Study. Asthma and COPD were each associated with increased risk for incident RA, independent of smoking status/intensity and other potential confounders. PubMed, Arthritis Rheumatol, 03/04/2020. (Also see Asthma)

Incidence and risk factors for reactivation from resolved hepatitis B virus (HBV) in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs (bDMARDs). HBV reactivation occurred in 4.6% of RA patients with resolved HBV during the treatment with bDMARDs and the absence of anti-HBs may be a risk factor for the reactivation of resolved HBV. PubMed, Int J Rheum Dis, 2019 Apr;22(4):574-582. (Also see Clinical Trials and Liver Involvement)

Increased Risk of Thyroid Dysfunction Among Patients With Rheumatoid Arthritis (RA). Our study provides strong evidence for the increased risk of thyroid dysfunction among RA patients. PubMed, Front Endocrinol (Lausanne), 2019 Jan 11;9:799.(Also see Thyroid Diseases)

Comorbidity in psoriatic arthritis (PsA) and rheumatoid arthritis (RA). High rates of comorbidity were found and the prevalence of depression, cardiovascular risk factors and other comorbidities were higher in PsA than RA participants. PubMed, Intern Med J, 07/26/2018. (Also see Psoriasis and Psoriatic Arthritis)

Anti-CCP antibodies and rheumatoid factor (RF) in systemic sclerosis: Prevalence and relationships with joint manifestations. The prevalence of RF and anti-CCP antibodies is relatively high in SSc, and joint involvement occurs frequently. PubMed, Adv Clin Exp Med, 07/19/2018. (Also see Antibodies)

Prevalence of overlap of antineutrophil cytoplasmic antibody associated vasculitis (AAV) with systemic autoimmune diseases: an unrecognized example of poliautoimmunity. The most common AAV phenotype was renal–limited vasculitis, and the most frequent overlap disease was rheumatoid arthritis. PubMed, Clin Rheumatol, 07/14/2018. (Also see Vasculitis)

Joint damage is amplified in rheumatoid arthritis (RA) patients with positive thyroid autoantibodies (TAbs). Our data showed that joint destruction was amplified in RA patients with an elevated presence of TAbs, which supports the importance and necessity of TAbs and thyroid function screening and monitoring in RA patient management in clinical practice. PubMed, PeerJ, 2018 Jan 4;6:e4216. (Also see Autoimmune Thyroid Diseases)

Salivary Gland Ultrasonography (US) as a Diagnostic Tool for Secondary Sjögren Syndrome (sSS) in Rheumatoid Arthritis (RA). Salivary gland US may aid the diagnosis of sSS in patients with RA. PubMed, J Rheumatol. (Also see Diagnosis of Sjögrens)

Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or rheumatoid arthritis (RA). The clinical manifestations of dermatomyositis/polymyositis were identified simultaneously with SSc and RA in the majority of cases, in contrast to identification in the SLE group. PubMed, Clin Rheumatol. (Also see Lupus in Overlap and Myopathy and Myositis)

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