Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
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Overview: What is Sarcoidosis?

Sarcoidosis KaleidoscopeSarcoidosis typically begins in the lungs, however it can affect any part of the body. The first symptom of sarcoidosis is usually shortness of breath.

What is Sarcoidosis? Sarcoidosis is an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands. In patients with sarcoidosis, abnormal masses or nodules (called granulomas) consisting of inflamed tissues form in certain organs of the body. These granulomas might alter the normal structure and possibly the function of the affected organ(s). Cleveland Clinic.

Sarcoidosis. Sarcoidosis is an inflammatory disease that starts in your lungs, but in time it can affect virtually any organ in your body, including your liver, skin, heart, nervous system and eyes. Mayo Clinic.


Genetics of sarcoidosis. Biology approaches will soon help unravel the differing and common features of sarcoidosis with other granulomatous disorders and also with diseases with significantly different phenotypes and allow the development of new therapeutic strategies and tools. PubMed, Semin Respir Crit Care Med, 2014 Jun;35(3):296-306.


Sarcoidosis Diagnosis. There is no single way to diagnose sarcoidosis, since all the symptoms and laboratory results can occur in other diseases. UCSF.

Case Report: Early diagnosis of early–onset sarcoidosis (EOS) with functional analysis and review of the literature. Skin rash with granuloma formation and specific NOD2 mutations may represent early diagnostic hallmarks of EOS in infants with persistent inflammation. PubMed, Clin Rheumatol.


Possible Signs and Symptoms. Shortness of breath (dyspnea) and a cough that won't go away can be among the first symptoms of sarcoidosis. But sarcoidosis can also show up suddenly with the appearance of skin rashes.

Sarcoidosis : Renal manifestations. Renal involvement in sarcoidosis is much more common than generally assumed from old epidemiological studies and is often only detected when actively searched for. PubMed, Z Rheumatol, 04/12/2017.

How are cancer and connective tissue diseases (CTDs) related to sarcoidosis? The association between sarcoidosis and both cancer and CTDs may yield important insights into the immunopathogenesis of all three diseases. PubMed, Curr Opin Pulm Med, 2015 Sep;21(5):517-24. (Also see Connective Tissue Disease and Cancer)


How is Sarcoidosis Treated? The goals of treatment are to improve how the organs affected by sarcoidosis work, relieve symptoms, shrink the granulomas. National Heart Lung and Blood Institute.

Current concepts regarding calcium metabolism and bone health in sarcoidosis. Vitamin D supplementation may be withheld in sarcoidosis patients with bone fragility, unless calcitriol levels are below normal limits. PubMed, Curr Opin Pulm Med, 2017 Sep;23(5):476-481.

Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy. Muscle biopsy specimens revealed an active inflammatory process and functional improvement after immunomodulatory treatment was significantly better in patients with short disease durations. PubMed, J Neurol, 2015 Apr;262(4):1035-45.

Sarcoidosis-associated pulmonary hypertension (SAPH) and lung transplantation for sarcoidosis. Lung transplantation is a viable therapeutic option for sarcoid patients with severe pulmonary fibrocystic sarcoidosis or SAPH refractory to medical therapy. PubMed, Semin Respir Crit Care Med, 2014 Jun;35(3):362-71.

Personal Stories

Debs B: Diffuse Systemic Sclerosis (England) This seems to be a long list of ailments that I have been coping with for years, so the addition of diffuse systemic sclerosis did not really panic me…

Missie R: Mixed Connective Tissue Disease I finally asked for an ANA test to check for lupus. My family doctor hesitated because my symptoms were all over the board…

Yolima: Diffuse Scleroderma I was misdiagnosed for more than a year with so many diseases and given all types of medication for different problems except for the real disease…

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