SCLERO.ORG
Search

Causes of Lipodystrophy or Lipoatrophy

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Autoimmune
Dermatomyositis
Electromagnetic Fields?
Gluten Sensitivity
Lupus
Panniculitis
Scleroderma
Sjogren's Syndrome
Thyroiditis

This page covers only localized lipodystrophy
that is caused by things other than AIDS/HIV or retroviral treatments.

Overview

Causes of lipodystrophy, other than HIV/Aids and retroviral treatment, include autoimmune diseases, dermatomyositis, diabetes, electromagnetic fields, gluten sensitivity, lupus, panniculitis, scleroderma, Sjogren's, and thyroiditis. (Also see Lipodystrophy)

Autoimmune Diseases

Localized Lipoatrophy can be a common sequela of panniculitis in patients with connective tissue diseases (eg, systemic lupus erythematosus, subcutaneous morphea, the syndrome of lobular lymphocytic connective tissue panniculitis of Winkelmann and Padilha-Goncalves). Lipoatrophy can be associated with nephritis, hypocomplementemia, scleroderma, Sjögren's syndrome, recurrent pyogenic infections, immune thrombocytopenic purpura (ITP), and thyroiditis. Medscape.

Lipodystrophy, Acquired Partial. Disorders associated with acquired partial lipodystrophy include membranoproliferative glomerulonephritis, and autoimmune diseases including (but not limited to) systemic lupus erythematosus, dermatomyositis, pernicious anemia, celiac disease, dermatitis herpetiformis, rheumatoid arthritis, temporal arteritis, leukocytoclastic vasculitis, POEMS, and diabetes. Medscape.

Primary Atrophic Solitary Morphea Profunda. Here, we describe a patient presenting with noninflammatory cupuliform (shaped like a small cup) depressed plaques, without any significant skin induration, pigmentation or texture change, that appeared on the left shoulder at a site of previous intramuscular vaccination. Our observation highlights the wide spectrum of clinical presentations of localized scleroderma. The latter should be considered in the presence of lipoatrophy-like lesions for proper workup and therapy. (Also see Causes of Scleroderma: Vaccinations and Morphea Profunda)

Dermatomyositis

Lipodystrophy may be a cutaneous marker for metabolic abnormalities in dermatomyositis.

Diabetes

Lipoatrophic diabetes mellitus can cause lipoatrophy.

Lack of AKT in adipocytes causes severe lipodystrophy. These data reveal the critical role of adipocyte AKT and insulin signaling for maintaining adipose tissue mass. PubMed, Mol Metab. 2016 May 13;5(7):472-9.

Electromagnetic Fields?

Lipoatrophia Semicircularis: a new office disease? 900 cases reported in Belgium. Since 1995, we have diagnosed more than 900 cases in our company. Based on our research, we believe that electromagnetic fields play an important role in this phenomenon. Curvers Bart, MD, ESD Journal.

Gluten Sensitivity

Dermatomyositis associated with celiac disease: response to a gluten-free diet. After she was put on a strict gluten-free diet, both nutritional deficiencies and the dermatomyositis resolved. The patient's human leukocyte antigen haplotype study was positive for DR3 and DQ2, which have been shown to be associated with both juvenile dermatomyositis and celiac disease. It is suggested that patients with newly diagnosed dermatomyositis be investigated for concomitant celiac disease even in the absence of gastrointestinal symptoms. Can J Gastroenterol.

Lupus

Partial Lipodystrophy in a Patient with Systemic Lupus erythematosus. A 54-year-old woman developed partial lipodystrophy on the left side of her face. She had been suffering from systemic lupus erythematosus (SLE) since 1985 when she was 45 years old. Dermatology.

Semicircular lipoatrophy in a child with systemic lupus erythematosus after subcutaneous injections with methotrexate. We report a 10-year-old girl who developed semicircular lipoatrophy on the anterior thighs after treatment of systemic lupus erythematosus (SLE) with subcutaneous injections of methotrexate. Pediatr Dermatol.

Panniculitis

Panniculitis. Panniculitis is inflammation of the subcutaneous fat. Fat is divided into lobules by connective tissue septae. These septae contain the blood supply supplying the lobule. Chart lists type of infiltrates associated by diseases, including lipoatrophy. The Doctor's Doctor.

Panniculitis: A summary. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. PubMed, Semin Diagn Pathol, 12/27/2016.

Cutaneous panniculitis. Frequently, the precise cause of panniculitis cannot be established from the outset and treatment can be challenging and is based on the histopathological findings. PubMed, Rev Med Interne, 2016 Nov;37(11):743-750.

Case Report: Lupus Panniculitis (LEP) as an Initial Manifestation of Systemic Lupus Erythematosus (SLE). Patients with LEP should have regular follow-ups because the development of SLE is possible and early diagnosis and proper treatment is pivotal to improve the prognosis of such patients. PubMed, Medicine (Baltimore).

Scleroderma

Primary Atrophic Solitary Morphea Profunda (SMP) is a distinct form of localized scleroderma, mimicking localized lipoatrophy. Our observation highlights the wide spectrum of clinical presentations of localized scleroderma. The latter should be considered in the presence of lipoatrophy-like lesions for proper workup and therapy. Karger Dermatology.

Case Reports: Sclerodermic linear lupus panniculitis. Lupus erythematosus panniculitis is a rare disease characterized by deep subcutaneous nodules, most commonly localized on the upper limbs and face. We present here the clinical characteristics, course and laboratory findings of 2 patients having linear lupus erythematosus panniculitis with localized scleroderma-like changes. PubMed, Dermatology. (Also see Linear Scleroderma)

Sjogren's Syndrome

Lipoatrophy can be a common sequela of panniculitis in patients with connective tissue diseases (eg, systemic lupus erythematosus, subcutaneous morphea, the syndrome of lobular lymphocytic connective tissue panniculitis of Winkelmann and Padilha-Goncalves). Lipoatrophy can be associated with nephritis, hypocomplementemia, scleroderma, Sjögren's syndrome, recurrent pyogenic infections, immune thrombocytopenic purpura (ITP), and thyroiditis. Emedicine. (Also see Sjogren's Syndrome)

Thyroiditis

Lipoatrophy can be a common sequela of panniculitis in patients with connective tissue diseases (eg, systemic lupus erythematosus, subcutaneous morphea, the syndrome of lobular lymphocytic connective tissue panniculitis of Winkelmann and Padilha-Goncalves). Lipoatrophy can be associated with nephritis, hypocomplementemia, scleroderma, Sjögren's syndrome, recurrent pyogenic infections, immune thrombocytopenic purpura (ITP), and thyroiditis. Emedicine. (Also see Thyroid Disease)

Go to Perioral Dermatitis
 
United Way of Central New Mexico
United Way of Snohomish County
See ISN News for recent donors, including memorials for
Jim Miller, Arlene Marie Petulla, Frances Maude Baldwin Watson and Rubye Mai Blocker Westmoreland.
Thanks to Winn Schillberg for donating to scleroderma research.
Donate or Shop Now
 

TOLL FREE HOTLINE, U.S. and Canada: 1-800-564-7099
Ask for our Free Info Packet by email or postal mail!

SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected] to request our Welcome email, or to report bad links or to update this page content. Privacy Policy.
 

The most important thing in the world to know about scleroderma is sclero.org!

Donate Now
Copyright 1998-2017, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.